A Microfluidic Organ-On-A-Chip: Into the Next Decade of Bone Tissue Engineering Applied in Dentistry

Syahruddin, Muhammad Hidayat; Anggraeni, Rahmi; Ana, Ika Dewi

doi:10.2144/fsoa-2023-0061

Cited by 5 publications

(2 citation statements)

References 266 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the current medical achievements are the so-called organs-on-a-chip (AOAC) systems [140][141][142]. These microscale devices combine tissue engineering features with microfluidic performance.…”

Section: Future Directionsmentioning

confidence: 99%

Application of Artificial Intelligence at All Stages of Bone Tissue Engineering

Kolomenskaya,

Butova,

Poltavskiy

et al. 2023

Biomedicines

View full text Add to dashboard Cite

The development of artificial intelligence (AI) has revolutionized medical care in recent years and plays a vital role in a number of areas, such as diagnostics and forecasting. In this review, we discuss the most promising areas of AI application to the field of bone tissue engineering and prosthetics, which can drastically benefit from AI-assisted optimization and patient personalization of implants and scaffolds in ways ranging from visualization and real-time monitoring to the implantation cases prediction, thereby leveraging the compromise between specific architecture decisions, material choice, and synthesis procedure. With the emphasized crucial role of accuracy and robustness of developed AI algorithms, especially in bone tissue engineering, it was shown that rigorous validation and testing, demanding large datasets and extensive clinical trials, are essential, and we discuss how through developing multidisciplinary cooperation among biology, chemistry with materials science, and AI, these challenges can be addressed.

show abstract

Section: Future Directionsmentioning

confidence: 99%

Application of Artificial Intelligence at All Stages of Bone Tissue Engineering

Kolomenskaya,

Butova,

Poltavskiy

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Since osseointegration is defined as the direct connection between living bone and a load-carrying endosseous implant at the microscopic level [11], animal models play a vital role in translational research investigating the osseointegration process. Although there is difficulty in translating findings from in vitro research to the clinical scenario, technological advancements are enabling us to create scenarios that mimic the dynamics of the human body using organ-on-a-chip technology [12]. Therefore, we critically reviewed all studies on various animal models studying the osseointegration degree of new implant surfaces, reporting different species used in the osseointegration research over the last 30 years.…”

Section: Introductionmentioning

confidence: 99%

Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades

Scarano,

Khater,

Gehrke

et al. 2024

JFB

View full text Add to dashboard Cite

Dental implants and bone augmentation are among dentistry’s most prevalent surgical treatments; hence, many dental implant surfaces and bone grafts have been researched to improve bone response. Such new materials were radiologically, histologically, and histomorphometrically evaluated on animals before being used on humans. As a result, several studies used animals to evaluate novel implant technologies, biocompatibility, surgical techniques, and osseointegration strategies, as preclinical research on animal models is essential to evaluate bioactive principles (on cells, compounds, and implants) that can act through multiple mechanisms and to predict animal behavior, which is difficult to predict from in vitro studies alone. In this study, we critically reviewed all research on different animal models investigating the osseointegration degree of new implant surfaces, reporting different species used in the osseointegration research over the last 30 years. Moreover, this is the first study to summarize reviews on the main animal models used in the translational research of osseointegration, including the advantages and limitations of each model and determining the ideal location for investigating osseointegration in small and large animal models. Overall, each model has advantages and disadvantages; hence, animal selection should be based on the cost of acquisition, animal care, acceptability to society, availability, tolerance to captivity, and housing convenience. Among small animal models, rabbits are an ideal model for biological observations around implants, and it is worth noting that osseointegration was discovered in the rabbit model and successfully applied to humans.

show abstract

Low‐Migration Compounds with Amine Functionality as Coinitiators of Radical Polymerization

Chen,

Schmitt,

Graff

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

The utilization of two‐component systems comprising camphorquinone (CQ) and aromatic amines has become prevalent in the photopolymerization of dental adhesives and composites. However, there are still concerns about the safety of this CQ/amine system, mainly because of the toxicity associated with the leaching of aromatic amines from dental materials. In light of these concerns, this study aims to develop novel co‐initiator combinations featuring CQ and amines which cannot be leached out of dental materials, enabling free radical polymerization of representative dental methacrylate resins under blue light irradiation. Our approach involved the initial design and analysis of hydrogen donors with low C‐H bond dissociation energy through molecular modeling. Subsequently, we incorporated copolymerizable methacrylate functional groups via chemical modification, allowing it to act as both coinitiator and copolymerization monomer to achieve low migration and leachability properties. This work presents, for the first time, the synthesis of the innovative co‐initiator and compares its performance with the benchmark CQ/ethyl‐4‐dimethylaminobenzoate (EDB)‐based photoinitiation system (PIS). The results demonstrate the effectiveness of the newly proposed PIS, with the comparable or superior polymerization properties were obtained when acrylate resins were subjected to photopolymerization using blue dental LEDs in ambient air. Furthermore, the system exhibited remarkable bleaching capabilities. Moreover, the elastic modulus of the resulting polymer was substantially enhanced. Finally, we conducted an in‐depth investigation into the reaction mechanism associated with this PIS through molecular orbital calculations and electron spin resonance studies.This article is protected by copyright. All rights reserved

show abstract

A Microfluidic Organ-On-A-Chip: Into the Next Decade of Bone Tissue Engineering Applied in Dentistry

Cited by 5 publications

References 266 publications

Application of Artificial Intelligence at All Stages of Bone Tissue Engineering

Application of Artificial Intelligence at All Stages of Bone Tissue Engineering

Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades

Low‐Migration Compounds with Amine Functionality as Coinitiators of Radical Polymerization

Contact Info

Product

Resources

About