A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

Sun, Jiashu; Xianyu, Yunlei; Li, Mengmeng; Liu, Wenwen; Zhang, Lu; Liu, Dingbin; Liu, Chao; Hu, Guoqing; Jiang, Xingyu

doi:10.1039/c3nr01289a

Cited by 88 publications

(79 citation statements)

References 22 publications

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“…The size of NMs plays an important role in affecting NMs cellular uptake via regulating the interactions between NMs and cells . Indeed, several studies about NMs cellular uptake in vitro suggest that various protein supplements in the cell culture media will also yield significantly different PC and interfere in the size of NMs, finally affecting their cellular uptake .…”

Section: Sizementioning

confidence: 99%

“…Such membrane‐wrapping process initiates receptor‐mediated endocytosis that requires the concerted formation of multiple interactions between NMs and cell membrane receptors . The size of NMs, to a larger extent, determines the contact area and contact pattern between NMs and cell membrane . The contact area and contact pattern will further affect NMs cellular uptake.…”

Section: Sizementioning

confidence: 99%

“…Actually, NMs cellular uptake is a very complex process and involves various uptake pathways. One of the most known pathways is phagocytosis which is defined as a process where phagocytes engulf solid NMs to form internal compartments to realize NMs cellular uptake . Moreover, several nonphagocytic pathways, such as clathrin‐mediated endocytosis, caveolae‐mediated endocytosis, and macropinocytosis, also play the roles in mediating NMs cellular uptake .…”

Section: Sizementioning

confidence: 99%

“…We used a microfluidic origami chip with various 3D geometries to synthesize monodisperse functionalized poly(lacticcoglycolic acid) (PLGA) nanoparticles by an enhanced mixing in 3D microchannels. As‐prepared PLGA nanoparticles with ≈100 nm have optimum interactions with cell membrane and realize a significantly improved cellular uptake …”

Section: Sizementioning

confidence: 99%

See 3 more Smart Citations

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

Liu

Workalemahu

Jiang

2017

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Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of NMs cellular uptake between in vitro and in vivo, a focus on reviewing recent works about the effects of four physicochemical parameters of NMs (size, rigidity, shape, surface modification) on regulating NMs cellular uptake in vitro and in vivo is undertaken. This review can provide readers some useful clues and new thinking for understanding NMs cellular uptake in depth.

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Section: Sizementioning

confidence: 99%

Section: Sizementioning

confidence: 99%

Section: Sizementioning

confidence: 99%

Section: Sizementioning

confidence: 99%

See 2 more Smart Citations

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

Liu

Workalemahu

Jiang

2017

Small

Self Cite

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“…Therefore, rapid and sufficient mixing is vital to generate small-sized and welldispersed nanoparticles. 19 Microfluidic-based nanoprecipitation enables the precise control of mixing on a small length scale, thus becoming a promising platform for the controlled synthesis of nanoparticles. 20 A major challenge for microfluidicbased synthesis, however, lies in the low productivity of nanoparticles, which is limited by the low flow rate ranging from hundreds of μL to several mL per hour inside microfluidic devices.…”

mentioning

confidence: 99%

A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

et al. 2014

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This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h −1 , resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.

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Electrozone Sensing Goes Nano

Figueiredo

Ferreira

Campos

2015

Encyclopedia of Analytical Chemistry

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Recent advances in nanopore‐based technologies and microelectronics allowed the resurgence of Coulter counter‐based techniques. Known collectively as resistive pulse sensing, this technique is now capable of characterizing nanoscale objects, such as nanoparticles, viruses, DNA, and other polymers, while keeping the main attractions of the classical versions: simplicity, sensitivity and resolution, and single‐object readout. Besides an accurate characterization of both size and concentration of the nanoparticles in their natural environment, additional information about particle surface charge is currently possible in an individual basis. Furthermore, efforts have been made to integrate the nanopores in microfluidic systems with the inherent advantages in terms of portability and cost as well as the ability to integrate multiple functions. This survey aims to review the progress in resistive pulse sensing toward the characterization of submicron particles, with special emphasis on nanopore design (natural and synthetic) and on lab‐on‐a‐chip devices.

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A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

Cited by 88 publications

References 22 publications

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

Electrozone Sensing Goes Nano

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