In this paper, the periodic structure material is modeled as the continuum homogeneous micro-polar media subjecting to thermo-mechanical interaction. Meanwhile, a series of equivalent quantities such as the equivalent stress, couple stress, displacement gradient and torsion tensor were defined by the integral forms of the boundary values of the external surface force, moment, displacement and the angular displacement, and were proved to satisfy the equivalence conditions of virtual work. Based on above works, the displacement boundary value problem was established to deduce the equivalent constitutive equation. Assume the representative volume element is composed of the spatial cross-framework, and applying the boundary value problem of displacement on frame structures, the equivalent elastic coefficients, temperature coefficients of equivalent stress and the temperature gradient coefficients of equivalent couple stress are deduced. In addition, the method can also be extended to the stress boundary value problem to deduce the equivalent constitutive equation. The calculations indicate that the equivalent result can be obtained from the two kinds of boundary value problems.