A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial

Manger, Mari S; McKenzie, Joanne E.; Winichagoon, Patttanee; Gray, Andrew; Chavasit, Visith; Pongcharoen, Tippawan; Gowachirapant, Sueppong; Ryan, Bill; Wasantwisut, Emorn; Gibson, Rosalind S.

doi:10.1093/ajcn/87.6.1715

Cited by 57 publications

(58 citation statements)

References 38 publications

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“…[21][22][23] A meta-analysis of multiple micronutrient supplementation showed a positive effect on child growth with effect sizes of 0.28 (95% confidence interval = 0.16-0.41) for height and 0.28 (95% confidence interval = -0.07 to 0.63) for weight. 24 Multiple micronutrient fortification showed a positive effect on growth in some studies 25,26 but not in other studies such as in school children in Thailand 27 and South Africa. 28 The present study investigated the impact of multi-micronutrient fortification in combination with de-worming in a school-based approach on growth, cognitive function, and parasite load among rural Vietnamese schoolchildren and whether combining the two interventions was more beneficial than either intervention alone.…”

Section: Introductionmentioning

confidence: 95%

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Nga

Winichagoon²,

Dijkhuizen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Micronutrient deficiencies are associated with impaired growth and cognitive function. A school-based fortification program might benefit schoolchildren but a high prevalence of parasite infestation might affect effectiveness. A randomized, double-blind, placebo-controlled 2 × 2 factorial trial was conducted to assess the efficacy of multimicronutrient fortified biscuits with or without de-worming on growth, cognitive function, and parasite load in Vietnamese schoolchildren. Schoolchildren (n = 510), 6-8 years of age were randomly allocated to receive albendazole or placebo at baseline and four months of multi-micronutrient fortified biscuits (FB) or non-fortified biscuits. Children receiving FB for four months scored higher on two cognitive tests: Raven's Colored Progressive Matrices and the Digit Span Forward test. Children receiving albendazole plus FB had the lowest parasite load after four months. In children receiving FB, midupper arm circumference was slightly improved (+0.082 cm) but there were no differences in other indexes of anthropometry. Combining multi-micronutrient fortified biscuits with de-worming is an effective strategy.

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Section: Introductionmentioning

confidence: 95%

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Nga

Winichagoon²,

Dijkhuizen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Seven of 8 studies 24,25,29,35,38,43,60 provided data which allowed comparison of the 2 extreme groups of vitamin D (Ͻ25 nmol/L and Ն50 nmol/L). The mean difference in MMSE between these groups was 1.4 (95% CI 0.6, 2.1), with some heterogeneity (I 2 ϭ 0.50; p ϭ 0.04).…”

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confidence: 99%

Vitamin D, cognition, and dementia

Balion

Griffith²,

Strifler³

et al. 2012

Neurology

404

345

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Objective: To examine the association between cognitive function and dementia with vitamin D concentration in adults.Methods: Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I 2 methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g. Results:Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State

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“…Our findings are in contrast to findings from three other trials in school children, which all showed benefits of a multiple MN supplementation on morbidity. A study in Thai children of 5-13 years of age, demonstrated a significantly beneficial effect of a MN fortified seasoning powder on the incidence of respiratory-related illness such as cough and runny nose and diarrhea (Manger et al, 2008). Similarly, in Indian children aged 5-14 years, a multiple MN fortified beverage was effective in reducing the mean duration of illness significantly with 2.4 days compared with an unfortified beverage (Sarma et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Multiple MN supplements may have a small effect on infectious morbidity (Allen et al, 2009), although the effects of different intervention trials have not been consistent. For example, in pre-school children, multiple MN supplements have been shown to be associated with lower respiratory or GI morbidity (Sharieff et al, 2006;Sazawal et al, 2007;Manger et al, 2008), but other studies have shown no effects (Smuts et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children

et al. 2011

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Background/Objectives: Few studies have shown that supplementation with micronutrients (MNs) or n-3 fatty acids may have health benefits such as reduced morbidity in schoolchildren. The effect of a combination of these nutrients has never been investigated. This study aimed to determine the effect of a combination of two different doses of MN and n-3 fatty acids on morbidity in schoolchildren in Bangalore, India. Subjects/Methods: In all 598 children (6-10 years) received foods fortified with either high (100% recommended dietary allowance) or low (15% recommended dietary allowance) MN, combined with either high (900 mg a-linolenic acid (ALA) plus 100 mg docosahexaenoic acid) or low (140 mg ALA) n-3 fatty acids for 1 year. Morbidity was measured by weekly self-reports using a structured questionnaire. Poisson regression analyses of episodes/child/year and duration/episode adjusted for age and sex were performed on clusters of symptoms, including upper and lower respiratory tract infections (URTI and LRTI), gastrointestinal complaints (GI) and general symptoms of illness to observe MN and n-3 fatty acid treatment effects. Conclusion: Although n-3 fatty acids may be beneficial for reducing illness in Indian schoolchildren, more research is needed to confirm presence of combined effect with MN.

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A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial

Cited by 57 publications

References 38 publications

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Decreased Parasite Load and Improved Cognitive Outcomes Caused by Deworming and Consumption of Multi-Micronutrient Fortified Biscuits in Rural Vietnamese Schoolchildren

Vitamin D, cognition, and dementia

The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children

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