A Micropuncture Assessment of the Effects of Contrast Media of Different Osmolality

Morsing, P.; Ae, Persson; Boberg, Ulf

doi:10.1097/00004424-198810000-00012

Cited by 11 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other factors which may underlie the GFR depression after injection of CM, in addition to an acute increase in the intratubular pressure, are changes in the tubuloglomerular feedback (TGF) system or direct influence on vasomotor tone in the arterioles (6,10,11,18). The osmotic diuresis caused by CM increases the urine flow to the macula densa, while the concentration of sodium chloride is reduced at the same site (5).…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Ueda¹,

Nygren²,

Hansell³

et al. 1993

Acta Radiol

View full text Add to dashboard Cite

The effect of i.v. injection of contrast media (CM, 1 600 mg I/kg b.w.) on proximal and distal tubular hydrostatic pressure (PTHP, DTHP) in the rat was investigated using a micropuncture technique. The PTHP and DTHP after injection of diatrizoate, iohexol, ioxaglate, or mannitol returned to control values within approximately 20 min. However, following iotrolan injection PTHP was still elevat ed above control levels after 35 min while DTHP remained elevated throughout the experiment (50 min). Iotrolan has a lower osmotic potential than the other CM when given in equivalent iodine doses. The concentration of iotrolan may thus increase more along the tubules than the other CM and consequently lead to a higher viscosity of urine, resulting in increases in PTHP and DTHP. The high intratubular pressure induced by iotrolan may explain our previous findings of reduced single nephron glomerular filtration rate caused by this CM.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Ueda¹,

Nygren²,

Hansell³

et al. 1993

Acta Radiol

View full text Add to dashboard Cite

show abstract

“…An effect on RPF might also be a consequence of increased TGF activity, since TGF probably acts by arteriolar vasoconstriction (20). Increases in tubular pressures during osmotic diuresis (7,15) would result in decreased net driving forces for glomerular filtration and subsequent reductions in GFR. The increased tubular pressures could also lead to increased interstitial pressures, which might affect the renal circulation.…”

Section: Discussionmentioning

confidence: 99%

Effects of High- and Low-Osmolar Contrast Media on Renal Plasma Flow and Glomerular Filtration Rate in Euvolaemic and Dehydrated Rats

Nygren¹,

Ulfendahl²,

Fasching³

1989

Acta Radiol

View full text Add to dashboard Cite

The effects of a slow intravenous injection of contrast media (CM) on renal function and haemodynamics were investigated in euvolaemic and dehydrated rats. Iodine-equivalent doses (1600 mg I1kg body weight) of ioxithalamate, ioxaglate, iopamidol and iohexol were used. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with clearance techniques. In euvolaemic rats no statistically significant decrease in GFR or RPF was found after CM injections. In the dehydrated rats the changes in GFR were more pronounced and this was significantly decreased in the ioxithalamate and iopamidol groups while RPF was still not decreased. This study indicates that dehydration potentiates adverse effects of CM on GFR and that there may be differences between the effects of low-osmolar and high-osmolar CM on GFR and also between different low-osmolar CM.

show abstract

“…The increase in tubular pressure during osmotic diuresis would result in a net decrease in the forces driving glomerular filtration (8, 23), and the increased interstitial pressure that follows might affect the microcirculation (26). However, it seems unlikely that this phenomenon could explain our results, since in dehydrated animals mannitol and iohexol solutions of equal osmolality did not induce similar effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Mannitol and Iohexol Infusions on the Renal Cortical Blood Flow in Dehydrated Mice

Högström¹,

Hietala²,

Rooth³

1996

Acta Radiol

View full text Add to dashboard Cite

A Micropuncture Assessment of the Effects of Contrast Media of Different Osmolality

Cited by 11 publications

References 0 publications

Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Effects of High- and Low-Osmolar Contrast Media on Renal Plasma Flow and Glomerular Filtration Rate in Euvolaemic and Dehydrated Rats

Effects of Mannitol and Iohexol Infusions on the Renal Cortical Blood Flow in Dehydrated Mice

Contact Info

Product

Resources

About