A Microscale Planar Linear Ion Trap Mass Spectrometer

Decker, Trevor K.; Zheng, Yuhua; Ruben, Aaron J.; Wang, Xiao; Lammert, Stephen A.; Austin, Daniel E.; Hawkins, Aaron R.

doi:10.1007/s13361-018-2104-x

Cited by 13 publications

(5 citation statements)

References 55 publications

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“…As opposed to focusing ions to a central point in the 3D ion trap, 2D ion traps confine ions in two dimensions allowing one free dimension for ion translocation thereby increasing the trapping capacity [99, 100]. Several geometries have been reported for miniaturized mass spectrometers including the linear ion trap (LIT) [101–103], rectilinear ion trap (RIT) [9], and toroidal ion trap (TIT) [12]. Due to its simplicity and increased trapping capacity, the LIT has been used as the mass analyzer in several portable mass spectrometers.…”

Section: Instrumentation Of Portable Mass Spectrometersmentioning

confidence: 99%

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Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

et al. 2022

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Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for 'omics analysis is provided.

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Section: Instrumentation Of Portable Mass Spectrometersmentioning

confidence: 99%

“…Several geometries have been reported for miniaturized mass spectrometers including the linear ion trap (LIT) [101][102][103], rectilinear ion trap (RIT) [9], and toroidal ion trap (TIT) [12]. Due to its simplicity and increased trapping capacity, the LIT has been used as the mass analyzer in several portable mass spectrometers.…”

Section: Ion Trap (It)mentioning

confidence: 99%

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

et al. 2022

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“…Also, the radial and axial frequencies are taken as ω r /2π = 1 MHz and ω z /2π = 50 kHz, respectively. According to the definition of the coupling coefficient (β ∝ tan θ/r 0 ), we consider high trap asymmetry by taking θ = π/4 and considering more confined traps with r 0 20 µm [41,42] to make the coupling stronger. For example, for r 0 ≈ 2 µm and using the aforementioned parameters, we find β/2π = 100 kHz.…”

Section: A Parametersmentioning

confidence: 99%

Quantum signatures in a quadratic optomechanical heat engine with an atom in a tapered trap

Izadyari

Öncü²,

Durak

et al. 2022

J. Opt. Soc. Am. B

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We investigate how quantum signatures can emerge in a single atom heat engine consisting of an atom confined in a tapered trap and subjected to hot and cold thermal reservoirs. A similar system was realized experimentally in Science 352, 325 (2016)SCIEAS0036-807510.1126/science.aad6320. We model such a system using a quadratic optomechanical model and identify an effective Otto cycle in the system’s dynamics. We compare the engine’s performance in quantum and classical regimes by evaluating the power dissipated. We find that lowering the temperature is insufficient to make the single atom engine in Science 352, 325 (2016)SCIEAS0036-807510.1126/science.aad6320 a genuine quantum-enhanced heat engine. We show that it is necessary to make the trap more asymmetric and confined to ensure that quantum correlations cause an enhancement in the power output.

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“…The capability to conduct data-independent analysis would be particularly valuable in miniature mass spectrometers where a discontinuous atmospheric pressure interface (DAPI) decreases instrument size at the cost of reduced duty cycle. 5 Improvements in MS/MS capabilities would then mirror recent improvements in mass range, 6 instrument size and power, 7 and resolution, 8 which have made miniature ion trap mass spectrometers attractive as on-site chemical sensors.…”

Section: ■ Introductionmentioning

confidence: 99%

Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans

Szalwinski

Snyder

Wells

et al. 2020

J. Am. Soc. Mass Spectrom.

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Two experiments are described that extend the capabilities of quadrupole ion trap mass spectrometers operated in the precursor and neutral loss scan mode. The first experiment, a triple resonance precursor ion scan, is used to enhance sensitivity, selectivity, and molecular coverage. This method augments the ion trap precursor ion scan with the application of a second excitation frequency to selectively activate first-generation (MS2) product ions as they are formed and produce second-generation (MS3) product ions, which are then mass-selectively ejected with a third auxiliary signal and detected. This single mass analyzer experiment can be equated to performing the sequential precursor ion scan in a multiple analyzer system (Anal. Chem. 1990, 62 (17), 1809–1818). The second capability demonstrated is “frequency tagging”, a method used to differentiate between ions ejected due to inherent instability under given trapping conditions, which causes artifacts during these scans, and ions that are resonantly ejected by the product ion ejection frequency. Beat frequencies are used to modulate resonance ejection peaks but conveniently do not modulate boundary ejection peaks. Frequency tagging provides a mechanism to identify the artifact peaks that are a consequence of operating at a high trapping voltage (i.e., low mass cutoff) for optimal precursor/product ion selectivity. The experiment is demonstrated for precursor and for neutral loss scans.

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A Microscale Planar Linear Ion Trap Mass Spectrometer

Cited by 13 publications

References 55 publications

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Quantum signatures in a quadratic optomechanical heat engine with an atom in a tapered trap

Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans

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