A Microstructural Study of Oedema Resolution

Naruse, Hirotsune; Tanaka, K.; Nishimura, Shüro; Fugimoto, K.

doi:10.1007/978-3-7091-9115-6_30

Cited by 2 publications

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“…Hattori et al (1990) using horseradish peroxidase made a morphological estimation of brain extracellular fluid dynamics in cold-induced edema in rat parietal cortex and postulated a retrogade transport by vessels as an important phenomenon for edema resolution. A similar study for edema resolution was carried out by Naruse et al (1990), using the infusion model, reporting the rapid flow of extracellular fluid via the perivascular space in cat brain and its important role in edema resolution. Pierpaoli et al (1993) made histopathological correlates of abnormal water diffusion in rat cerebral ischemia using diffusion weight magnetic resonance and electron microscopy.…”

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confidence: 99%

The Extracellular Space in the Edematous Human Cerebral Cortex: An Electron Microscopic Study Using Cortical Biopsies

Castejón

2009

Ultrastructural Pathology

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In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to abnormal accumulation of cerebrospinal fluid. In brain trauma, the distended extracellular space contained either electron-lucid nonproteinaceous or electron-dense proteinaceous edema fluid. Hemorrhagic foci, fibrinoid material, and non-nervous invading cells, such as macrophages and monocytes, were also found. In brain tumors, the widened extracellular space showed electron-dense proteinaceous edema fluid and bundles of fibrinoid material. The enlarged extracellular space found in congenital hydrocephalus, vascular anomalies, brain trauma, and tumors is closely related to the clinical symptoms exhibited by the patients under study.

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confidence: 99%

The Extracellular Space in the Edematous Human Cerebral Cortex: An Electron Microscopic Study Using Cortical Biopsies

Castejón

2009

Ultrastructural Pathology

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“…Hattory et al using horseradish peroxidase made a morphological estimation of brain extracellular fluid dynamics in cold-induced edema in rat parietal cortex, and postulated a retrogade transport by vessels as an important phenomenon for edema resolution [16]. A similar study for edemaresolution carried out by Naruse et al, using the infusion model, reported the rapid flow of extracellular fluid via the perivascular space in cat brain, and its important role in edema resolution [17]. Pierpaoli et al made anhistopathological correlates of abnormal water diffusion in rat cerebral ischemia using diffusion weight magnetic resonance and electron microscopy [18].…”

Section: Introductionmentioning

confidence: 93%

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2018

JCRC

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The enlargement and content of perivascular and extracellular spaces in experimental and human material have been reviewed. The human edematous cerebral cortex associated to vascular anomaly, congenital hydrocephalus, brain trauma, and brain tumors were examined by transmission electron microscopy, using cortical biopsies of frontal, parietal, and temporal cortex. In congenital hydrocephalus, the pre-existing extracellular space that features immature cerebral cortex appears notably enlarged and occupied by electron transparent, non-proteinaceous interstitial edema fluid, due to the abnormal accumulation of non-circulating cerebrospinal fluid. In severe human brain trauma associated to subdural or estradural hematomas and brain tumors, the distended extracellular space contains either electron lucid non-proteinaceous edema fluid, and electron dense proteinaceous edema fluid, fibrinoid material, exosomes or extracellular vesicles, extracellular mitochondria, hemorrhagic foci, and non-nervous invading cells, such as phagocytic astrocytes, macrophages, microglia, and monocytes. In brain tumors, the widened extracellular space shows mainly electron dense proteinaceous edema fluid, and bundles of fibrinoid material and extracellular vesicles.

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A Microstructural Study of Oedema Resolution

Cited by 2 publications

References 5 publications

The Extracellular Space in the Edematous Human Cerebral Cortex: An Electron Microscopic Study Using Cortical Biopsies

The Extracellular Space in the Edematous Human Cerebral Cortex: An Electron Microscopic Study Using Cortical Biopsies

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