A microvascularizedin vitroliver model for disease modeling and drug discovery
Flavio Bonanini,
Roelof Dinkelberg,
Manuel Caro Torregrosa
et al.
Abstract:Drug discovery for complex liver diseases faces alarming attrition rates. The lack of non-clinical models that recapitulate key aspects of liver (patho)-physiology is likely contributing to the inefficiency of developing effective treatments. Of particular notice is the common omission of an organized microvascular component despite its importance in maintaining liver function and its involvement in the development of several pathologies. Increasing the complexity ofin vitromodels is usually associated with a … Show more
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