A Mild and Efficient Procedure for Dehydration of Primary Carboxamides to Nitriles by Silyl Sulphonyl Polyphosphates

A novel synthesis of tolunitriles by selective ammoxidation

“…Tolunitriles are traditionally synthesized from the dehydration of amide [6] or aldoxime [7], cyanation of aryl chloride [8,9] or of toluic acid [10,11] and diazotization of toluidine [12], etc. However, these methods usually require expensive starting materials or lead to serious pollution and are not suitable for industrial production on a large scale.…”