A Mild and Facile Route to ω-Amino Esters

Five-, Six-, and Seven-membered Lactim Ethers. Methods of Synthesis and Chemical Properties. (Review)

“…The salts of the lactim ether 24, formed with high yields by the action of gaseous hydrogen chloride (diethyl ether, 25) or hydrofluoroboric acid (methylene chloride, 5°C) on the corresponding lactim ethers, are converted by the action of water at room temperature into the salts of the esters of ω-amino carboxylic acids 25 [16,17]. The reaction of valerolactim methyl ether with methyl fluorosulfonate (9) gives an 80% yield of the fluorosulfate 26 [24,39] …”

“…The heating of lactams with dimethyl sulfate [2][3][4][5][6][7][8][9][10][11][12][13][14][15], or more rarely diethyl sulfate [4,5,[15][16][17], is the most widely used method for the synthesis of lactim ethers (Table 1).…”

“…The second method in frequency of use for the production of lactim ethers is the treatment of lactams with trialkyloxonium fluoroborates 4 at 20-25°C [3,4,[16][17][18][19][20][21] (Table 2).…”

Cobalt-catalyzed synthesis of ε-caprolactam and nylon-6 from aminopentene and carbon monoxide

“…The procedure similar to that reported for N-(trimethylsilyl)-2-pyrrolidinone was used [9]. The crude product was distilled under vacuum at 40 • C to give a colorless oil.…”

Modular Routes Towards New N,O‐Bidentate Ligands Containing an Electronically Delocalised β‐Enaminone Chelating Backbone

“…1 2-Cyano-4,4,5,5,6,6,6-heptafluoro-1-methyl-3-oxohex-1-enylamino}ethylamino}eth-(Z)-ylidene]-4,4,5,5,6,6,6- Supporting Information (see also the footnote on the first page of this article): Preparation details and full characterisation of com- pounds 1-3, 7-12, 16-23, 26, 30-35, 42-47, 49, 51 and 52; refs. [44,[46][47][48] refer to material in the Supporting Information.…”