A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

Zm, Liu; Sc, Ho; Ym, Chen; Yp, Ho

doi:10.1038/ijo.2009.236

Cited by 27 publications

(30 citation statements)

References 46 publications

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“…The green tea catechin EGCG has produced positive effects on body mass and composition in animals (Bose et al 2008;Ito et al 2008). Although quercetin had no effect on body mass or composition in the current study, small effects on body mass have been observed with tea catechins (Hase et al 2001;Nagao et al 2001Nagao et al , 2007Harada et al 2005) and other polyphenols such as soy flavonoids (Jenkins et al 2002;Liu et al 2009). However, Park et al (2008) found that a combination of genistein, quercetin, and resveratrol was more effective at inhibiting adipogenesis and inducing apoptosis in human adipocytes than any individual compound alone.…”

Section: Discussioncontrasting

confidence: 51%

“…The obesity pandemic has accelerated cell, animal, and human research on the anti-obesity effects of flavonoids (Borchardt and Huber 1975;Melzig 1996;Hase et al 2001;Nagao et al 2001Nagao et al , 2005Nagao et al , 2007Singh et al 2003;Alexander 2006;Greenberg et al 2006;Harwood et al 2007;Bose et al 2008;Egert et al 2008;Ito et al 2008;Stewart et al 2008;Liu et al 2009;Faria et al 2010;Grove and Lambert 2010;Zhu et al 2010). For example, several animal studies indicate that 3-15 weeks of supplementation with green tea extract and epigallocatechin gallate (EGCG) reduce body mass and fat mass (Bose et al 2008;Ito et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Other polyphenols such as soy isoflavones demonstrate positive effects on weight loss in humans. For example, 6 months of supplementation with 15 g soy protein and 100 mg isoflavones significantly reduced body mass and body fat percentage in postmenopausal Chinese women (Liu et al 2009). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45%normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements adminis-tered in double-blind fashion: Q500 = 500 mg quercetin·day-1, Q1000 = 1000 mg quercetin·day-1, and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition meas-urements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and com-position across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a dose-responsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant dif-ferences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, fe-males p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body mass or body composition were found in a subgroup of overweight and obese subjects. High-dose quercetin supplementation (500 and 1000 mg·day-1) for 12 weeks in a large, heterogeneous group of adults did not affect body mass or composition. Abstract: In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45% normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements administered in double-blind fashion: Q500 = 500 mg quercetin·day -1 , Q1000 = 1000 mg quercetin·day -1 , and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition measurements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and composition across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a doseresponsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant differences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, females p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body ma...

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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show abstract

“…Soy protein intake has been found to be related to a mild favorable effect on bone mass and weight reduction in postmenopausal Chinese women. [52][53] Being a high-quality protein source and containing isoflavones with estrogen-like effect, soy protein might contribute to the preserving effect of LM. More research on this area in perimenopausal women is warranted.…”

mentioning

confidence: 99%

Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women

Chan

et al. 2010

Int J Obes

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Objectives: Whether age or menopause per se influences fat distribution remains controversial. This study aimed to investigate the change of body composition, particularly body fat distribution, in relation to menopausal transition in a 30-month prospective study of perimenopausal women. Methods: A total of 438 community-based healthy women aged 44-55 years participated in the Hong Kong Perimenopausal Women Osteoporosis Study. Data were obtained at baseline, and at 9-, 18-and 30-month during the follow-up. Soft tissue measurements consisting of fat mass and lean muscle mass of the trunk and whole body were obtained by the dual energy X-ray absorptiometry. Percentage change of body measurements over the follow-up period was compared between women who remained premenopausal, those who went through menopausal transition, and those who were menopausal since baseline. Results: A slight decrease in the lean mass but an increase in the total fat mass and trunk fat mass (TFM) over the follow-up period were noted. Multivariate linear regression analysis showed that age was negatively associated with an increase in central obesity. Adjusted for the important predictorsFage, age of menarche and education level, menopausal status was a significant and independent predictor of the decrease in lean mass and the increase in percent of body fat, TFM and trunk-leg fat mass ratio. Conclusion: Our 30-month longitudinal study showed that menopause has an independent effect on an increase in fat mass, and an increase in central obesity in perimenopausal Chinese women.

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“…However, soy protein and isoflavones of soybeans might play an important role. SupplementaInt J Food Nutr Sci | Volume 2: Issue 1 www.ommegaonline.com Soybean/Brown Rice Consumption in Postmenopausal Women tion with 15 g soy protein and 100 mg isoflavones affected the BW, BMI, and body fat reductions in Chinese postmenopausal women [17] . In our study, there were 8.7 ± 1.2 g of soy protein and 22.0 ± 3.0 mg of isoflavones in the SBR supplement; these contents were lower than supplements given in the above study.…”

Section: Discussionmentioning

confidence: 99%

Effects of soybean/brown rice consumption on body fat and blood lipids in overweight postmenopausal women

Chien

Liou

Kao³

et al. 2015

IJFNS

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A menopause-induced estrogen deficiency might increase body-fat accumulation, insulin resistance, and abnormal blood sugar and lipids. Thus, postmenopausal women have a high risk of cardiovascular diseases. Some studies indicated that soy can improve the syndrome of menopause, and whole-grain foods can reduce blood cholesterol concentrations. In the present study, under a 1200-kcal diet, overweight postmenopausal women ingested soybean/brown rice (SBR) as their grains for lunch for 12 weeks, and the effects on the anthropometric profile, body composition, blood profile, and plasma isoflavone levels were assessed. After 12 week of SBR intake, dietary fiber intake (21.5 ± 6.7 g) was higher than that of the control group. Body weight (BW), waist circumference (WC), hip circumference (HC), and the waist-hip ratio (WHR) had decreased in both groups. The body-fat percentage and android-fat percentage had also decreased in both groups. Blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) did not change during the intervention period. In the SBR and control groups, serum triglycerides (TGs) decreased, and high-density lipoprotein cholesterol (HDL-C) rose. In contrast, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) had decreased in the SBR group at 12 weeks compared with week 0. Diastolic blood pressure (DBP) significantly decreased in the SBR group. Changes in dietary fiber and soy protein intake were significantly negatively correlated with the body-fat percentage and gynoid-fat percentage changes. In conclusion, under energy restriction, SBR intake can reduce serum TC, LDL-C, and DBP in overweight postmenopausal women.

show abstract

A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

Cited by 27 publications

References 46 publications

Quercetin with vitamin C and niacin does not affect body mass or composition

Quercetin with vitamin C and niacin does not affect body mass or composition

Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women

Effects of soybean/brown rice consumption on body fat and blood lipids in overweight postmenopausal women

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