A Mild, High-Yield Conversion of Aldoximes into Nitriles using Trichloroacetyl Chloride/Triethylamine

Spin Delocalization by Triple-Bonded Functionalities in Propargyl and Heteropropargyl Radicals, Assessed from the EPR-Spectral D Parameter of 1,3-Cyclopentanediyl Triplet Diradicals

“…The cyano-substituted A1 azoalkane was obtained from the corresponding oxime 2a through dehydration with trichloromethyl chloroformate 16 in acetonitrile. The isonitrile-and acetylene-functionalized azoalkanes A′2 and A′3 were synthesized by Horner-Emmons olefination of the azoaldehyde A with the respective known phosphonates in THF.…”

A novel synthesis of tolunitriles by selective ammoxidation

“…Tolunitriles are traditionally synthesized from the dehydration of amide [6] or aldoxime [7], cyanation of aryl chloride [8,9] or of toluic acid [10,11] and diazotization of toluidine [12], etc. However, these methods usually require expensive starting materials or lead to serious pollution and are not suitable for industrial production on a large scale.…”

Solvent‐free Synthesis of Nitriles from Aldehydes Catalyzed by KF/Al2O3, Montmorillonite KSF and K10

“…3 The conversion of aldehydes into the corresponding nitriles is an important organic transformation. This procedure is usually achieved by dehydration of the corresponding aldoximes using classical reagents 4 or new milder ones such as phosphorus diiodide, 5 trichloro-acetyl chloride, 6 chlorosulfonyl isocyanate, 7 or chlorosulfonyl fluoride. 8 Bejoy Thomas 9 has reported conversion of aldehydes oxime into nitriles using solid acid as catalysts, but it needs high temperature and long reaction time.…”