A Mild Metal‐Free Approach for the Direct Synthesis of Carbamoyl Azides from Carboxylic Acid Redox Active Esters
Yan‐Hua Qiu,
Yuping Zhu,
Ming‐Hua Rao
et al.
Abstract:Carbamoyl azide is an important compound which was transformed into urea, amine and applied to nitrene insertion reaction. We developed a novel metal‐ and oxidant‐free method for the direct synthesis of carbamoyl azide from acid redox active esters. A variety of functional groups were tolerated. In addition, the late‐stage modification of natural products and drugs paves the way for the design and finding new drug lead molecules.
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