2016
DOI: 10.1158/0008-5472.can-16-2631
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A Milestone Review on How Macrophages Affect Tumor Growth

Abstract: learning how macrophages exert distinct effects on tumor pathophysiology based on their response to the specific microenvironment of tumors that they rove. This review also helped popularize the nomenclature of tumor-associated macrophages, or TAM, now a widely understood moniker used broadly in the field. Key Messages from the ReviewTAM infiltration was already shown to correlate with poor prognosis of cancer patients. The central message of this seminal review from Drs. Lewis and Pollard was that different T… Show more

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Cited by 92 publications
(69 citation statements)
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“…Importantly, MDSCs and M2 tumor-associated macrophages not only impede tumor immune surveillance but also support tumor cell proliferation via cytokine production, and could thereby foster growth of K-RAS-driven lung AC. 38,45 In line with these data, ruxolitinib treatment of mouse autochthonous lung tumors mainly affected the expression of pro-tumorigenic chemokines and cytokines. This chemokine/cytokine milieu is well-known to be a central modulator of the cancer microenvironment and it has been established as one of the hallmark drivers of cancer.…”
Section: Discussionmentioning
confidence: 52%
See 1 more Smart Citation
“…Importantly, MDSCs and M2 tumor-associated macrophages not only impede tumor immune surveillance but also support tumor cell proliferation via cytokine production, and could thereby foster growth of K-RAS-driven lung AC. 38,45 In line with these data, ruxolitinib treatment of mouse autochthonous lung tumors mainly affected the expression of pro-tumorigenic chemokines and cytokines. This chemokine/cytokine milieu is well-known to be a central modulator of the cancer microenvironment and it has been established as one of the hallmark drivers of cancer.…”
Section: Discussionmentioning
confidence: 52%
“…On the other hand, systemic JAK inhibition triggered a slight reduction of tumor promoting M2 macrophages and significantly reduced the abundance of infiltrating granulocytic and monocytic MDSCs, which is in agreement with an induction of an antitumorigenic TME and the antitumor effects of ruxolitinib. Importantly, MDSCs and M2 tumor‐associated macrophages not only impede tumor immune surveillance but also support tumor cell proliferation via cytokine production, and could thereby foster growth of K‐RAS‐driven lung AC . In line with these data, ruxolitinib treatment of mouse autochthonous lung tumors mainly affected the expression of pro‐tumorigenic chemokines and cytokines.…”
Section: Discussionmentioning
confidence: 60%
“…However, studies within that same research period show that M2 macrophages have a central role in tumor propagation [37]. The M2 cells drive tumor development in both primary and metastatic sites through their contributions in basement membrane breakdown and deposition, angiogenesis, recruitment of leukocytes, and overall immune suppression [37][38][39]. It is important to note that, like normal homeostasis, macrophages within TME are not limited to M1/M(LPS) or M2/M(IL-4) states; they may reside in-between or off this spectrum.…”
Section: Macrophages In Tumorigenesismentioning
confidence: 99%
“…During cancer development, a complex microenvironment is formed, generating a unique set of signals impacting infiltrating immune cells. One consequence is the accumulation of tumor‐associated macrophages (TAMs), which are often abundantly present in malignant solid tumors and have been associated with tumor invasion, migration and angiogenesis, as well as worse clinical outcome …”
Section: Introductionmentioning
confidence: 99%