A millisecond micromixer via single-bubble-based acoustic streaming

Ahmed, Daniel; Mao, Xiaole; Shi, Jinjie; Juluri, Bala Krishna; Huang, Tony Jun

doi:10.1039/b903687c

Cited by 373 publications

(282 citation statements)

References 36 publications

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“…Nevertheless, RNW streaming can describe the flow in these cases quite accurately. 157 Within a typical microfluidic experimental setup 149,156 the streaming velocity is on the order of mm/s to cm/s, which makes the manipulation of the liquid and particles in microchannels using oscillating bubbles a powerful yet efficient and simple technique compared to electrokinetics and electrophoresis. 144,[166][167][168] Recently, Wang et al 156,157 used the cavitation microstreaming of a bubble together with Poiseuille flow to manipulate particles and their spatial concentration for enrichment, filtering and focusing applications in microfluidic devices.…”

Section: A Cavitation Microstreamingmentioning

confidence: 99%

“…They are greatly beneficial in a number of proposed applications in chemical, biological, and physical processes such as mixing, [149][150][151] pumping, 152,153 characterizing enzymatic reactions, 154 cell lysis, 155 and sorting and enrichment. 156,157 A thorough review article on applications of oscillating microbubbles in microfluidics is recently written by Hashmi et al 158 Although, there are a number of techniques to generate bubbles in microfluidic channels, 159,160 using a cavity is found to be the simplest.…”

Section: A Cavitation Microstreamingmentioning

confidence: 99%

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Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

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Focusing and sorting cells and particles utilizing microfluidic phenomena have been flourishing areas of development in recent years. These processes are largely beneficial in biomedical applications and fundamental studies of cell biology as they provide cost-effective and point-of-care miniaturized diagnostic devices and rare cell enrichment techniques. Due to inherent problems of isolation methods based on the biomarkers and antigens, separation approaches exploiting physical characteristics of cells of interest, such as size, deformability, and electric and magnetic properties, have gained currency in many medical assays. Here, we present an overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels. Our emphasis is on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows. We also highlight the advantages and drawbacks of each method in terms of throughput, separation efficiency, and cell viability. Finally, we discuss the future research areas for extending the scope of hydrodynamic mechanisms and exploring new physical directions for microfluidic applications.

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Section: A Cavitation Microstreamingmentioning

confidence: 99%

Section: A Cavitation Microstreamingmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

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“…Such microbubbles have been used in a number of microfluidics applications including transport and trapping, 12,13 micro-mixing, 14,15 and cell deformation and lysis. 16 While the bubbles are actively driven to oscillation, the particles in the bubble streaming flows experience size-dependent effects due to flow forces only, allowing us to trap and sort them passively, without the use of any external forces or small-scale geometric features.…”

Section: Introductionmentioning

confidence: 99%

Particle migration and sorting in microbubble streaming flows

Thameem

Hilgenfeldt

2016

Biomicrofluidics

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Ultrasonic driving of semicylindrical microbubbles generates strong streaming flows that are robust over a wide range of driving frequencies. We show that in microchannels, these streaming flow patterns can be combined with Poiseuille flows to achieve two distinctive, highly tunable methods for size-sensitive sorting and trapping of particles much smaller than the bubble itself. This method allows higher throughput than typical passive sorting techniques, since it does not require the inclusion of device features on the order of the particle size. We propose a simple mechanism, based on channel and flow geometry, which reliably describes and predicts the sorting behavior observed in experiment. It is also shown that an asymptotic theory that incorporates the device geometry and superimposed channel flow accurately models key flow features such as peak speeds and particle trajectories, provided it is appropriately modified to account for 3D effects caused by the axial confinement of the bubble. V C 2016 AIP Publishing LLC.

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“…Here, the high frequency oscillation generates a unidirectional, non-zero, time-averaged velocity component, which is called "micro streaming" [41]. The micro streaming flows have been applied to micropumps or micromixers [42,43].…”

Section: Propulsion By Bubblesmentioning

confidence: 99%

Mini and Micro Propulsion for Medical Swimmers

Feng

Cho

2014

Micromachines

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Mini and micro robots, which can swim in an underwater environment, have drawn widespread research interests because of their potential applicability to the medical or biological fields, including delivery and transportation of bio-materials and drugs, bio-sensing, and bio-surgery. This paper reviews the recent ideas and developments of these types of self-propelling devices, ranging from the millimeter scale down to the micro and even the nano scale. Specifically, this review article makes an emphasis on various propulsion principles, including methods of utilizing smart actuators, external magnetic/electric/acoustic fields, bacteria, chemical reactions, etc. In addition, we compare the propelling speed range, directional control schemes, and advantages of the above principles.

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A millisecond micromixer via single-bubble-based acoustic streaming

Cited by 373 publications

References 36 publications

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Particle migration and sorting in microbubble streaming flows

Mini and Micro Propulsion for Medical Swimmers

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