A mimic of bronchogenic carcinoma - pulmonary melioidosis

Zhao, Joseph J; Yap, Ashton; Wu, Eric Q.; Yap, J. C. H.

doi:10.1016/j.rmcr.2020.101006

Cited by 6 publications

(9 citation statements)

References 5 publications

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“…46 articles with a total of 70 patients were selected for full text review. 15 articles, with a total of 29 patients were excluded due to insufficient clinical information (n = 12) [ 1 , 3 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ] or no report of microbiological diagnosis (n = 3) [ 21 , 22 , 23 ]. A total of 31 articles [ 5 , 10 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ] with 41 patients met the inclusion criteria of this systematic review.…”

Section: Resultsmentioning

confidence: 99%

Melioidosis and the Heart: A Systematic Review

Velusamy

Muhi

2020

TropicalMed

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Melioidosis is caused by Gram-negative bacterium Burkholderia pseudomallei. Clinical presentation can vary from pneumonia, sepsis and multi-focal abscess formation. The aim of this study was to systemically review the cardiac manifestations of melioidosis in the literature and describe their epidemiology, microbiological diagnosis and outcomes. A systematic review of the peer-reviewed literature was carried out in PubMed and Google Scholar for human melioidosis cases with cardiac involvement. Quantitative data for cases of melioidosis were obtained, including age, sex, microbiological diagnosis, treatment, and outcome. 980 articles were screened, of which 31 articles were eligible. The most common cardiac site of infection was pericarditis, followed by endocarditis and myocarditis. Over 95% of cardiac involvement occurred in males, and mortality was the lowest in pericarditis and highest in myocarditis. Valvular vegetations were all small, left-sided, and did not require surgery. Antibiotic treatment included a bactericidal induction therapy with ceftazidime or a carbapenem ± TMP-SMX, followed by eradication therapy with TMP–SMX in most patients as previously established. In conclusion, melioidosis varies in clinical presentation and is also known as a great imitator. Although cardiac involvement is rare, this is the first systematic review to summarise all cases reported in the literature to date.

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Section: Resultsmentioning

confidence: 99%

Melioidosis and the Heart: A Systematic Review

Velusamy

Muhi

2020

TropicalMed

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“…However, mediastinal lymphadenopathy is an uncommon feature of melioidosis [ 2 , 6 , [16] , [17] , [18] ]. Several case reports have described melioidosis with mediastinal lymphadenopathy, which can present as necrotic nodes and may be mistaken for tuberculosis or malignancy, posing a diagnostic challenge [ 11 , 15 , [19] , [20] , [21] , [22] , [23] , [24] ]. Initial blood cultures can yield negative results in cases of mediastinal melioidosis, similar to our case [ [19] , [20] , [21] ].…”

Section: Discussionmentioning

confidence: 99%

EBUS-TBNA diagnosis of mediastinal melioidosis in patient presented with lymphadenopathy and SVC thrombosis: A rare manifestation in non-diabetic patient

Jirawat,

Sriprasart

2024

Respiratory Medicine Case Reports

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“…Melioidosis is also known as the "great mimicker" owing to its variety of presentations which can sometimes mimic bronchogenic carcinoma, 104 Staphylococcal pneumonia, 105 or tuberculosis. 106 A prospective, 6-month cross-sectional single-center study at a Cambodian provincial referral hospital among 404 patients with suspicion of tuberculosis showed that one percent of patients had culture-proven respiratory melioidosis.…”

Section: Pulmonary Melioidosismentioning

confidence: 99%

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

Virk

Mukhopadhyay

Wiersinga

2020

Semin Respir Crit Care Med

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AbstractMelioidosis, caused by the facultative intracellular gram-negative pathogen Burkholderia pseudomallei, is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of B. pseudomallei in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Innovative environmental studies are also uncovering how hydrodynamic, pedology, fauna, and weather events influence geographic distribution and incidence of melioidosis cases. Of concern is the changes associated with global warming, which will be conducive to B. pseudomallei in combination with the global diabetes pandemic. In fact, over 80% of patient developing melioidosis have underlying comorbidities. For this great mimicker, culture remains the mainstay of diagnosis and despite availability of other assays, challenges still remain in reducing time to diagnosis and avoiding misdiagnosis. With institution of timely antimicrobials such as ceftazidime and supportive intensive care, overall mortality can be reduced to 10%, although this can still be as high as 50% in poorly resourced areas. Promise is on the horizon with the first human vaccine trials being planned for 2021. Meanwhile new multiomics techniques are giving us a better understanding of the role of virulence and host–pathogen interactions on patient outcomes.

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A mimic of bronchogenic carcinoma - pulmonary melioidosis

Cited by 6 publications

References 5 publications

Melioidosis and the Heart: A Systematic Review

Melioidosis and the Heart: A Systematic Review

EBUS-TBNA diagnosis of mediastinal melioidosis in patient presented with lymphadenopathy and SVC thrombosis: A rare manifestation in non-diabetic patient

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

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