Aero‐engine turbine blades are subject to combined high and low cycle fatigue (CCF) loadings during operations. In this paper, a modified nonlinear cumulative damage model is developed based on linear damage accumulation theory and static toughness exhaustion to predict the CCF life of turbine blades and common blade materials. An interaction factor is created to reflect the integrated effect of high cycle fatigue and low cycle fatigue (HCF‐LCF). Available test data from TC4 alloy and other two alloy materials, together with two turbine blades are utilized to validate the robustness and accuracy of the proposed approach. Comparative results demonstrate that the proposed model holds better performance in life predictions under CCF loadings.