A mini-review: mechanism of antimicrobial action and application of surfactin

Chen, Xiaoyu; Lu, Yajun; Shan, Mengyuan; Zhao, Hongyuan; Lu, Zhaoxin; Lu, Yingjian

doi:10.1007/s11274-022-03323-3

Cited by 67 publications

(41 citation statements)

References 79 publications

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“…For instance, Hu et al (2020) reported that amyloid–polyphenol hybrid nanofilaments can mitigate colitis and regulate gut microbial dysbiosis. In addition, surfactin is a bacterial amphiphilic lipopeptide with antibacterial and antiviral biological activities . It has a cyclic heptapeptide headgroup with the sequence Glu-Leu-D-Leu-Val-Asp-D-Leu-Leu linked to a C 13–15 β-hydroxy fatty acid by a lactone bond .…”

Section: Introductionmentioning

confidence: 99%

Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance

Chen

Zhao

et al. 2023

J. Agric. Food Chem.

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Ulcerative colitis (UC) is associated with brain neurotransmitter disorders and intestinal dysbiosis. Bacillus amyloliquefaciens fmb50 produces the lipopeptide surfactin, which has a wide range of biological activities. However, the effects of surfactin on DSS-induced colitis have not been reported. In the present study, oral surfactin significantly ameliorated colitis in a mouse model and reduced depression-like behavior, such as slowed walking speed, shortened movement distance in the open field test, and weakened exploration ability in the light–dark shuttle test. Surfactin noticeably improved gut microbial dysbiosis, intestinal barrier dysfunction in the colon, and blood–brain barrier dysfunction in the brain. Furthermore, the colon levels of occludin were upregulated by 68.51%, and the brain levels of occludin and ZO-1 were upregulated by 77.81% and 36.42%, respectively. Surfactin supplementation also inhibited inflammatory responses by inactivating the tumor necrosis factor-α (TNF-α), nuclear factor kappa-B (NF-κB), and NLRP3 signaling pathways in the colon and brain. Thus, we believe that surfactin improved the behavioral disorders by upregulating the levels of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF), suppressing the inflammatory responses, and improving the blood–brain barrier dysfunction. Surfactin also reduced the abundances of gut microbes that are related to colitis, especially targeting facultative anaerobes of the phylum Proteobacteria, and it increased the abundance of beneficial bacteria such as Lactobacillus and unidentified Prevotella. Combined with its nontoxic nature observed in this long-term study in mice, oral surfactin might be a promising intervention strategy for preventing colitis by acting on the microbiota-gut–brain axis.

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Section: Introductionmentioning

confidence: 99%

Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance

Chen

Zhao

et al. 2023

J. Agric. Food Chem.

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“…Additionally, the contribution of surfactin from the perspective of biocontrol is defined by its intense biosurfactant activity and the support in biofilm formation [ 18 ]. When it comes to the usual mechanisms of antimicrobial activity expressed by the surfactin lipopeptides, physico-chemical activity is reflected in cell membrane disintegration or osmotic pressure imbalance, followed by the inhibition of protein synthesis and enzyme activity, resulting in the reduced or completely inhibited metabolic activity and reproduction of the phytopathogens [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

Dairy and Wine Industry Effluents as Alternative Media for the Production of Bacillus-Based Biocontrol Agents

et al. 2022

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Food industry effluents represent one of the major concerns when it comes to environmental impact; hence, their valorization through different chemical and biological routes has been suggested as a possible solution. The vast amount of organic and inorganic nutrients present in food industry effluents makes them suitable substrates for microbial growth. This study suggests two valorization routes for whey as dairy industry effluent and flotation wastewater from the wine industry through microbial conversion to biocontrol agents as value-added products. Cultivations of the biocontrol strain Bacillus sp. BioSol021 were performed in a 16 L bioreactor to monitor the bioprocess course and investigate bioprocess kinetics in terms of microbial growth, sugar substrate consumption and surfactin synthesis, as an antimicrobial lipopeptide. The produced biocontrol agents showed high levels of biocontrol activity against mycotoxigenic strains of Aspergillus flavus, followed by a significant reduction of sugar load of the investigated effluents by the producing microorganisms. With proven high potential of whey and winery flotation wastewater to be used as substrates for microbial growth, this study provides grounds for further optimization of the suggested valorization routes, mostly in terms of bioprocess conditions to achieve maximal techno-economical feasibility, energy saving and maximal reduction of effluents’ organic and inorganic burden.

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“…We found that the SBLF improves the health and growth performance of broilers and pigs by modulating the microbiota [ 13 , 14 ]. Recent studies show that surfactin exerts multiple functions, including anti-bacterial activity [ 23 ], anti-cancer activity [ 24 ] and anti-inflammatory activity [ 25 ]. Based on HPLC analysis, SBLF contains around 1.43% surfactin.…”

Section: Discussionmentioning

confidence: 99%

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Tsai

Wong

Hsu

et al. 2022

Animals

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Inflammatory bowel disease (IBD) is a non-infectious disease characterized by chronic inflammation of the gastrointestinal tract. Currently, management of IBD is still a clinical challenge. The purpose of this study was to investigate the therapeutic potential of surfactin containing Bacillus licheniformis-fermented products (SBLF) and commercial surfactin (CS) on the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. We found that mice that received drinking water containing 3% DSS developed significant colitis symptoms, including increased disease activity index, body weight loss, shortening of the colon length, splenomegaly, colonic inflammation and colonic NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. Notably, orally received SBLF, CS or clinical anti-inflammatory drug 5-aminosalicylic acid improved DSS-induced colitis symptoms in mice. These findings show that SBLF can improve IBD in mice by reducing colonic inflammation and inhibiting the NLRP3 inflammasome activation, suggesting that SBLF has the potential to be used as a nutraceutical in humans or a feed additive in economic and companion animals for preventing IBD.

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A mini-review: mechanism of antimicrobial action and application of surfactin

Cited by 67 publications

References 79 publications

Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance

Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance

Dairy and Wine Industry Effluents as Alternative Media for the Production of Bacillus-Based Biocontrol Agents

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

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