A mini review of MAR-binding proteins

Wang, Tianyun; Zhou, Han; Chai, Yurong; Zhang, Junhe

doi:10.1007/s11033-010-0003-8

Cited by 44 publications

(30 citation statements)

References 64 publications

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“…Besides providing a structural framework to nucleoplasm, peripheral and nucleoplasmic lamins [28,101] together with their interacting partners [70] and the other NM components [14,[102][103][104] play important roles in epigenetics, chromatin organization, DNA replication and repair, transcription, and their dynamics. DNA replication takes place in a fixed number of sites liked to NM [105].…”

Section: Nm Lamins Genome Architecture and Metabolismmentioning

confidence: 99%

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

Cau

Navarro

Harhouri

et al. 2014

Seminars in Cell & Developmental Biology

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Lamin A-related progeroid syndromes are genetically determined, extremely rare and severe. In the past ten years, our knowledge and perspectives for these diseases has widely progressed, through the progressive dissection of their pathophysiological mechanisms leading to precocious and accelerated aging, from the genes mutations discovery until therapeutic trials in affected children. A-type lamins are major actors in several structural and functional activities at the nuclear periphery, as they are major components of the nuclear lamina. However, while this is usually poorly considered, they also play a key role within the rest of the nucleoplasm, whose defects are related to cell senescence. Although nuclear shape and nuclear envelope deformities are obvious and visible events, nuclear matrix disorganization and abnormal composition certainly represent the most important causes of cell defects with dramatic pathological consequences. Therefore, lamin-associated diseases should be better referred as laminopathies instead of envelopathies, this later being too restrictive, considering neither the key structural and functional roles of soluble lamins in the entire nucleoplasm, nor the nuclear matrix contribution to the pathophysiology of lamin-associated disorders and in particular in defective lamin A processing-associated aging diseases. Based on both our understanding of pathophysiological mechanisms and the biological and clinical consequences of progeria and related diseases, therapeutic trials have been conducted in patients and were terminated less than 10 years after the gene discovery, a quite fast issue for a genetic disease. Pharmacological drugs have been repurposed and used to decrease the toxicity of the accumulated, unprocessed and truncated prelaminA in progeria. To date, none of them may be considered as a cure for progeria and these clinical strategies were essentially designed toward reducing a subset of the most dramatic and morbid features associated to progeria. New therapeutic strategies under study, in particular targeting the protein expression pathway at the mRNA level, have shown a remarkable efficacy both in vitro in cells and in vivo in mice models. Strategies intending to clear the toxic accumulated proteins from the nucleus are also under evaluation. However, although exceedingly rare, improving our knowledge of genetic progeroid syndromes and searching for innovative and efficient therapies in these syndromes is of paramount importance as, even before they can be used to save lives, they may significantly (i) expand the affected childrens' lifespan and preserve their quality of life; (ii) improve our understanding of aging-related disorders and other more common diseases; and (iii) expand our fundamental knowledge of physiological aging and its links with major physiological processes such as those involved in oncogenesis.

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Section: Nm Lamins Genome Architecture and Metabolismmentioning

confidence: 99%

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

Cau

Navarro

Harhouri

et al. 2014

Seminars in Cell & Developmental Biology

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“…The matrix attachment region (MAR), which is also called the scaffold attachment region, is a stretch of AT-rich DNA sequence (ATR) that guides binding of genomic DNA to the nuclear matrix (10,11). Therefore, MAR acts as a structural determinant of chromatin organization and recruits multiple MAR-binding factors that facilitate remodeling of the chromatin structure in regulating gene expression (12).…”

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confidence: 99%

“…Various MAR-binding factors have been identified in yeast, animals, and plants (11,12). A major group of the MAR-binding factors possesses a protein motif, called AT-hook that consists of 9 -12 residues (13).…”

mentioning

confidence: 99%

The AT-hook Motif-containing Protein AHL22 Regulates Flowering Initiation by Modifying FLOWERING LOCUS T Chromatin in Arabidopsis

Yun

Kim²,

Jung

et al. 2012

Journal of Biological Chemistry

105

136

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“…Its constituents, the S/MAR proteins, interact both with one another and with chromatin thus keeping the cell's nucleus 'tidy' (Wang et al 2010). Here we focused on two particular S/MAR-binding proteins that are involved in the initiation of XCI: One is the Xist RNA localising factor hnRNP U/SAF-A that seems to tether Xist to chromatin.…”

Section: Discussionmentioning

confidence: 99%

A scaffold for X chromosome inactivation

Tattermusch

Brockdorff

2011

Hum Genet

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X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly understood. Accumulating evidence suggests that chromosome and nuclear organisation are important in both processes. Notably, recent studies have identified specific factors, previously shown to be components of the nuclear matrix or scaffold, to play a role both in Xist RNA-binding and in Xist-mediated silencing. In this review we provide a perspective on these studies in the context of previous work on chromosome/nuclear architecture in XCI.

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A mini review of MAR-binding proteins

Cited by 44 publications

References 64 publications

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

The AT-hook Motif-containing Protein AHL22 Regulates Flowering Initiation by Modifying FLOWERING LOCUS T Chromatin in Arabidopsis

A scaffold for X chromosome inactivation

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