A mini review on chemistry and biology of Holoptelea integrifolia Roxb. Planch (Ulmaceae)

Kumar, Dinesh; Kumar, Karunesh; Gupta, Jyoti; Bishnoi, Navita; Kumar, Sunil

doi:10.1016/s2221-1691(12)60384-0

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…Holoptelea integrifolia, whose fruit extract is chosen for our cytotoxic activity, is a globally famous traditional plant being used as an astringent, anthelmintic, acid gastritis lessening agent and wound healing promoter [23]. Stem bark of the plant has phytoconstituents named holoptelin-A and B, friedlin, epifredlin, hederagenin, 1,4-naphthalenedione that exhibits remarkable anti-bacterial activity [24].…”

Section: Resultsmentioning

confidence: 99%

Anticancer Activity of Five Traditionally Used Medicinal Plants' Extracts

Rizwani

Wang

Ahmed

et al. 2014

J. Can. Res. Updates

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Natural products play a critical role in cancer prevention and therapy today. There are numbers of anticancer agents from natural products used in the clinic.Fighting cancers with novel natural products, especially those extracted from plants, is a potential strategy to develop new anticancer drugs..In the following study, various extracts of well known medicinal plants named Holoptelea integrifolia (F), Operculina turpethum (R), Cardiospermem halicacabum L (S), Dilonix regia (F), Sesbania grandifora seed have been studied for evaluating their anticancer activity. Our data showed that the cytotoxic activity of Operculina turpethum (R) ethanolic extractwas relative high for all 6 cancer cell lines as compared to other extracts. The active compound and anticancer mechanism of these extracts are worth investigating in the future.

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Section: Resultsmentioning

confidence: 99%

Anticancer Activity of Five Traditionally Used Medicinal Plants' Extracts

Rizwani

Wang

Ahmed

et al. 2014

J. Can. Res. Updates

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“…Standardization of Holoptelea integrifolia (Roxb) Planch was performed using internationally acceptable assays and analysis [10] i.e., for pharmacognostic identification microscopic, macroscopic, sensory, and histological examinations were performed. Physiochemical examinations were determined by measuring extractive value, moisture contents and ash value.…”

Section: Standardizationmentioning

confidence: 99%

“…Pooled fractions (10 and 11) were re-chromatographed with chloroform to get 1-40 fractions. Similar fractions (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) and (14-40) were pooled. Fraction (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) was re-chromatographed with chloroform to get 1-38 fractions.…”

Section: Column Chromatographymentioning

confidence: 99%

“…Similar fractions (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) and (14-40) were pooled. Fraction (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) was re-chromatographed with chloroform to get 1-38 fractions. Similar fractions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were pooled and combined with previous left-over fractions (14-40) (isocratic) and subjected to CC with chloroform to get fractions (1-23).…”

Section: Column Chromatographymentioning

confidence: 99%

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A Triterpenoid Having Anticancer Activity Found in Stem Bark of Holoptelea integrifolia (Roxb.) Planch

Hassan¹,

Rasheed²,

Ali³

et al. 2018

Nat Prod Chem Res

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Studies on the chemical constituents of the stem bark of Holoptelea integrifolia (Roxb.) Planch have led to the isolation of a triterpenoid, oleanolic acid (1), the structure of the compound was elucidated via advanced spectroscopic techniques including EI (+), IR, 1 H-NMR and 13 C-NMR. Oleanolic acid was isolated first time from the stem bark of H. integrifolia. Crude ethylacetate extract of the stem bark of H. integrifolia has been tested in vitro for its cytotoxicity by MTT assay. This paper is based on isolation and characterization of the chemical constituents.

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“…This compromises the biocompatibility of the NPs, and hence limits the applications of the NPs in particular in biomedicine, which could have a harmful impact on the environment and human being. In fact, the presence of residual hazardous chemical species on the surface of the synthesized NPs cannot be removed easily and could prohibit their biological and clinical applications [30].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Selected Nanoparticles for Biomedical Applications

Ramirez-Perez

2023

austinjnanomednanotechnol

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Nanoparticles (NPs) are materials with a size scale of 100 nm or less. They are produced using a combination of chemical and physical techniques, and frequently include the use of hazardous substances. These hazardous substances are difficult to remove from nanoparticle surfaces, making them bioincompatible and limiting their application as biomedical nanoparticles. Nanoparticles can currently be synthesized biologically using methods based on green chemistry. The fusion of nanotechnology and biology has given rise to a new field called nanobiotechnology, which aims to harness biological entities such as actinomycetes, algae, bacteria, fungi, viruses, yeast, and plants in a number of physicochemical, biochemical, and biophysical processes. Plant extracts have been used in biological applications because they are a rich source of phytomolecules and because their capping and reducing capabilities have been used in the production of metal and metal oxide NPs. The biosynthesized NPs have not only been examined for their antibacterial, antifungal, antioxidant, anticancer, and biocompatibility properties but also for their morphology using a number of analytical techniques. This approach, which is affordable and environmentally friendly, could substitute traditional chemical and physical methods for biomedical applications.

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A mini review on chemistry and biology of Holoptelea integrifolia Roxb. Planch (Ulmaceae)

Cited by 12 publications

References 13 publications

Anticancer Activity of Five Traditionally Used Medicinal Plants' Extracts

Anticancer Activity of Five Traditionally Used Medicinal Plants' Extracts

A Triterpenoid Having Anticancer Activity Found in Stem Bark of Holoptelea integrifolia (Roxb.) Planch

Biosynthesis of Selected Nanoparticles for Biomedical Applications

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