A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry

Sharma, Vikas; Sharma, Prabodh Chander; Kumar, Vipin

doi:10.1016/j.jare.2014.11.002

Cited by 29 publications

(12 citation statements)

References 53 publications

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“…Alkaloids are defined by the presence of a heterocyclic nitrogen atom, and have been increasingly attracting pharmaceutical researchers to develop therapeutic agents as lead compounds [1][2][3]. Indole alkaloids are characterized by the presence of a structural moiety of indole, and have been extensively studied as they possess important biological properties such as antihypertension [4], antihistamine [5], anticonvulsant [6], anti-leishmanial [7], antidiabetic [8], anti-HIV-1, anti-inflammatory [9], anticancer [10], and antibacterial activities [11].…”

Section: Introductionmentioning

confidence: 99%

Novel Deep Eutectic Solvent Based on Levulinic Acid and 1,4-Butanediol as an Extraction Media for Bioactive Alkaloid Rutaecarpine

Sun

Liu

et al. 2019

Processes

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Deep eutectic solvents (DESs) are increasingly receiving interest as a new type of green and sustainable alternative to hazardous organic solvents. In this work, a novel DES based on levulinic acid (La) and 1,4-butanediol (Buta) as an extraction media was developed for extracting the bioactive alkaloid rutaecarpine from the unripe fruits of Tetradium ruticarpum. 24 different DESs consisting of choline chloride, betaine, sugar alcohols, organic acids, amides, and sugars were prepared and tailored to test their extraction efficiency. After initial screening, a hydrophilic DES composed of La and Buta with 1:0.5 molar ratio containing 25% water was tailored for the highest extraction efficiency, followed by the optimizations of molar ratio and water content. The interaction between the molecules of La-Buta DES was investigated by nuclear magnetic resonance spectroscopy in order to confirm its deep eutectic supermolecular structure feature. The extraction conditions were optimized by single-factor experiments, including extraction temperature, extraction time, and solid-liquid ratio. The developed La-Buta DES extraction procedure was successfully applied for the analysis of rutaecarpine in Chinese patent medicines containing the unripe fruits of T. ruticarpum. The excellent property of La-Buta DES indicated its potential as a promising green solvent instead of conventional organic solvent for the extraction of rutaecarpine from the unripe fruits of T. ruticarpum, and that it can used as a sustainable and safe extraction media for other applications.

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Section: Introductionmentioning

confidence: 99%

Novel Deep Eutectic Solvent Based on Levulinic Acid and 1,4-Butanediol as an Extraction Media for Bioactive Alkaloid Rutaecarpine

Sun

Liu

et al. 2019

Processes

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“…SLIRP silencing was achieved by using a pool of small interfering RNA (siRNA) and the downregulation of SLIRP was observed both at protein ( Figure 4a) and mRNA levels (Figures 5c, e and f). We evaluated the response of cells to camptothecin (CPT) and cisplatin (DDP), drugs able to activate the apoptotic program in several experimental models 22,23 by performing an Annexin V/propidium iodide (PI) staining that allows the discrimination of viable cells (Annexin V . As shown in Figure 4b, CPT treatment induced 40% of early and~20% of late apoptotic/necrotic events in H1299 control cells, whereas in accordance with the known anti-apoptotic function of bcl-2, it induced apoptosis or necrotic cell death in less than 10% in bcl-2-overexpressing cells.…”

Section: Resultsmentioning

confidence: 99%

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein

D’Aguanno¹,

Trisciuoglio²,

Desideri³

et al. 2016

European Journal of Cancer

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“…These azaoxoaporphine alkaloids were isolated and their structure elucidated for the first time in 1986 by Rao et al [98], and their biological activities were reported three years later. Sampangine was isolated as a potential antifungal and antimycobacterial agent, but sampangine also displayed in vitro antimalarial and anticancer activities [99][100][101][102][103]. All these biological properties are related to their basic structure, which corresponds to a class of marine-derived alkaloids named pyridoacridine [102].…”

Section: Sampanginementioning

confidence: 99%

Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects

et al. 2019

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Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. One of the most studied sources for anticancer therapy is natural compounds and their derivates, like alkaloids, which are organic molecules containing nitrogen atoms in their structure. Among them, oxoisoaporphine and sampangine compounds are receiving increased attention due to their potential anticancer effects. Boldine has also been tested as an anticancer molecule. Boldine is the primary alkaloid extract from boldo, an endemic tree in Chile. These compounds and their derivatives have unique structural properties that potentially have an anticancer mechanism. Different studies showed that this molecule can target cancer cells through several mechanisms, including reactive oxygen species generation, DNA binding, and telomerase enzyme inhibition. In this review, we summarize the state-of-art research related to oxoisoaporphine, sampangine, and boldine, with emphasis on their structural characteristics and the relationship between structure, activity, methods of extraction or synthesis, and anticancer mechanism. With an effective cancer therapy still lacking, these three compounds are good candidates for new anticancer research.

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A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry

Abstract: Graphical abstract

Cited by 29 publications

References 53 publications

Novel Deep Eutectic Solvent Based on Levulinic Acid and 1,4-Butanediol as an Extraction Media for Bioactive Alkaloid Rutaecarpine

Novel Deep Eutectic Solvent Based on Levulinic Acid and 1,4-Butanediol as an Extraction Media for Bioactive Alkaloid Rutaecarpine

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein

Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects

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