A Mini Review on the Functional Biomaterials Based on Poly(lactic acid) Stereocomplex

Jing, Yihan; Quan, Changyun; Liu, Bo; Jiang, Qing; Zhang, Chao

doi:10.1080/15583724.2015.1111380

Cited by 89 publications

(66 citation statements)

References 165 publications

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“…Poly( l ‐lactide) [i.e., poly( l ‐lactic acid) (PLLA)] is a biobased polymer derived from renewable plant materials and can be used in various applications such as commodity, industrial, biomedical, pharmaceutical, and environmental applications . Stereocomplex (SC) formation between PLLA and its enantiomer poly( d ‐lactide) [i.e., poly( d ‐lactic acid) (PDLA)] enhances the mechanical performance and hydrolytic/thermal degradation resistance and, therefore, stereocomplexed materials are extensively studied as advanced poly(lactide) [i.e., poly(lactic acid) (PLA)]‐based materials . In the case of blends, that the molecular architectures such as molecular weight and tacticity or optical purity of PLA polymers have crucial effects on SC crystallization and high molecular weight and low optical purity should be avoided because these factors disturb SC crystallization .…”

Section: Introductionmentioning

confidence: 99%

“…Stereocomplex (SC) formation between PLLA and its enantiomer poly( d ‐lactide) [i.e., poly( d ‐lactic acid) (PDLA)] enhances the mechanical performance and hydrolytic/thermal degradation resistance and, therefore, stereocomplexed materials are extensively studied as advanced poly(lactide) [i.e., poly(lactic acid) (PLA)]‐based materials . In the case of blends, that the molecular architectures such as molecular weight and tacticity or optical purity of PLA polymers have crucial effects on SC crystallization and high molecular weight and low optical purity should be avoided because these factors disturb SC crystallization . On the other hand, binary, ternary, and quaternary SC crystallization of optically active unsubstituted and/or substituted PLAs, and copolymers having opposite configurations and the identical or two different chemical structures have been reported and extensively studied .…”

Section: Introductionmentioning

confidence: 99%

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Stereocomplex‐ and Homo‐Crystallization and Phase‐Transition Behavior of Relatively High‐Molecular‐Weight Linear One‐ and Two‐Armed and Star‐Shaped Four‐Armed Poly(l‐lactide)/Poly(d‐lactide) Blends

Tsuji

Sakamoto

Arakawa

2017

Macro Chemistry & Physics

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Relatively high‐molecular‐weight linear one‐ and two‐armed and star‐shaped four‐armed poly(l‐lactide) and poly(d‐lactide) are synthesized and the multiplicate effects of arm‐number (branching architecture, coinitiator moiety), crystallization temperature (Tc), and number‐average molecular weight (Mn) on stereocomplex (SC)‐ and homo‐crystallization and phase‐transition behavior are investigated. For nonisothermal and isothermal crystallization, in addition to SC crystallites, homo‐crystallites are formed in the blends with higher Mn values, irrespective of arm number. For isothermal crystallization, the transition Tc ranges below which in addition to SC crystallites, homo‐crystallites are formed depended on Mn per one arm‐determining melting temperature or thickness of homo‐crystallites. The transition Mn ranges above which in addition to SC crystallites, homo‐crystallites are formed are not affected by arm number. The high molecular weight disturbs the change of crystalline growth mechanism of one‐ and two‐armed blends, whereas the branching architecture inhibits the change of crystalline growth mechanism of four‐armed blends.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stereocomplex‐ and Homo‐Crystallization and Phase‐Transition Behavior of Relatively High‐Molecular‐Weight Linear One‐ and Two‐Armed and Star‐Shaped Four‐Armed Poly(l‐lactide)/Poly(d‐lactide) Blends

Tsuji

Sakamoto

Arakawa

2017

Macro Chemistry & Physics

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“…In the case of high molecular weight PLA, the stereocomplex melting point is about 50 °C higher (230 °C) than that of the PLLA or PDLA homopolymers (180 °C), and the melting enthalpy value reported in the literature (reflecting polymer crystallinity) for 100% crystalline stereocomplex prepared from high molecular weight PLA is 142 J g −1 (145 J g −1 by other authors) whereas one of the reported melting enthalpies of PLLA homocrystallites is 93 J g −1 . The stabilization of PLA‐based micelles (PLA/poly(ethylene oxide) or PLA with other hydrophilic block copolymers) by the introduction of PLA stereocomplex into the micelle structure has been applied by many authors and this type of stereocomplex implementation dominates . Apart from micelles formed in a water medium, different solid (nano)microparticles based on PLLA and PDLA copolymers were also prepared by the application of such methods as solvent evaporation, precipitation, lowering solvent temperature or spray droplet atomization .…”

Section: Introductionmentioning

confidence: 95%

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Wojtczak

Gadzinowski

Makowski

et al. 2018

Polymer International

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Among different drug‐containing formulations prepared from biodegradable polymers, those based on polylactide (PLA) (usually block copolymers with poly(ethylene glycol)) are the most frequently developed and improved. A new easy method of such drug delivery system preparation with the application of PLA stereocomplexation is presented. The encapsulation of hydrophobic vitamins such as D3, E and A by spontaneous precipitation of microparticles with an average diameter of 1–2 µm led to a loading of about 10 wt% and an encapsulation efficiency in the range 27%–45% when a vitamin:PLA weight ratio of 3:10 was applied. SEM, TEM, X‐ray photoelectron spectroscopy and nitrogen absorption analysis of neat and vitamin‐loaded microparticles indicate a porous structure of the microparticles and confirm the presence of vitamins inside with an enriched surface layer. The release of vitamins into a phosphate buffer (pH 7.4) at 37 °C takes place at a low rate according to almost zero‐order kinetics (35%–60% of vitamin over 4 weeks). © 2018 Society of Chemical Industry

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“…The obtained mixture was purified by silica-gel column chromatography using a solution of n-hexane and ethyl acetate (v/v = 70/30, R f = 0.6) as an eluent, yielding 1.07 g (7.2 mmol, 48%) of clear liquid. 1 …”

Section: Preparation Of 2-chloro-ε-caprolactone (Fcl)mentioning

confidence: 99%

“…Over the past few decades, several thermogelling materials have been investigated extensively for a broad range of biomedical applications, such as in drug-or cell-delivery carriers [1]. Thermogelling materials can absorb water and swell in aqueous environments, which allow them to retain large amounts of fluids [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Pendant Group-Functionalized Diblock Copolymers with Adjustable Thermogelling Behavior

Lee

Park

et al. 2017

Polymers

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Abstract:Recently, several thermogelling materials have been developed for biomedical applications. In this study, we prepared methoxy polyethylene glycol (MPEG)-b-(poly(ε-caprolactone)-ran-poly(2-chloride-ε-caprolactone) (PCL-ran-PfCL)) (MP-Cl) diblock copolymers at room temperature via the ring-opening polymerization of caprolactone (CL) and 2-chloride-ε-caprolactone (fCL) monomers, using the terminal alcohol of MPEG as the initiator in the presence of HCl. MPEG-b-(poly(ε-caprolactone)-ran-poly(2-azide-ε-caprolactone) (PCL-ran-PCL-N 3 )) (MP-N 3 ) was prepared by the reaction of MP-Cl with sodium azide. MPEG-b-(poly(ε-caprolactone)-ran-poly(2-amine-ε-caprolactone) (PCL-ran-PCL-NH 2 )) (MP-NH 2 ) was subsequently prepared by Staudinger reaction. MP-Cl and MP-N 3 showed negative zeta potentials, but MP-NH 2 had a positive zeta potential. MP-Cl, MP-N 3 , and MP-NH 2 solutions formed opaque emulsions at room temperature. The solutions exhibited a solution-to-hydrogel phase transition as a function of the temperature and were affected by variation of the chloride, azide, and the amine pendant group, as well as the amount of pendant groups present in their structure. Additionally, the phase transition of MP-Cl, MP-N 3 , and MP-NH 2 copolymers was altered by pendant groups. The solution-to-hydrogel phase transition was adjusted by tailoring the crystallinity and hydrophobicity of the copolymers in aqueous solutions. Collectively, MP-Cl, MP-N 3 , and MP-NH 2 with various pendant-group contents in the PCL segment showed a solution-to-hydrogel phase transition that depended on both the type of pendant groups and their content.

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A Mini Review on the Functional Biomaterials Based on Poly(lactic acid) Stereocomplex

Cited by 89 publications

References 165 publications

Stereocomplex‐ and Homo‐Crystallization and Phase‐Transition Behavior of Relatively High‐Molecular‐Weight Linear One‐ and Two‐Armed and Star‐Shaped Four‐Armed Poly(l‐lactide)/Poly(d‐lactide) Blends

Stereocomplex‐ and Homo‐Crystallization and Phase‐Transition Behavior of Relatively High‐Molecular‐Weight Linear One‐ and Two‐Armed and Star‐Shaped Four‐Armed Poly(l‐lactide)/Poly(d‐lactide) Blends

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Preparation of Pendant Group-Functionalized Diblock Copolymers with Adjustable Thermogelling Behavior

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