A miniaturized all-in-one optical nose based on 3D printing technology and patterned paper substrate for discrimination of volatile organic compounds

Pesaran, Shiva; Shojaeifard, Zahra; Tashkhourian, Javad; Hemmateenejad, Bahram

doi:10.1016/j.snb.2022.132889

Cited by 9 publications

(5 citation statements)

References 54 publications

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“…In this regard, paper-based sensors like the O-nose system have been developed as cheap, facile, disposable, and portable analytical tools [7,8]. In our research group, several studies have been investigated in paper-based O-noses in various applications [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Paper-Based Biomimetic Sensing Device for the Discrimination of Original and Fraudulent Cigarette Brands Using Mixtures of MoS2 Quantum Dots and Organic Dyes

2023

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In this study, we investigated the combined effects of MoS2 QDs’ catalytic properties and the colorimetric responses of organic reagents to create a sniffing device based on the sensor array concept of the mammalian olfactory system. The aim was to differentiate the volatile organic compounds (VOCs) present in cigarette smoke. The designed optical nose device was utilized for the classification of various cigarette VOCs. Unsupervised Principal Component Analysis (PCA) and supervised Linear Discriminant Analysis (LDA) methods were employed for data analysis. The LDA analysis showed promising results, with 100% accuracy in both training and cross-validation. To validate the sensor’s performance, we assessed its ability to discriminate between five cigarette brands, achieving 100% accuracy in the training set and 82% in the cross-validation set. Additionally, we focused on studying four popular Iranian cigarette brands (Bahman Kootah, Omega, Montana Gold, and Williams), including fraudulent samples. Impressively, the developed sensor array achieved a perfect 100% accuracy in distinguishing these brands and detecting fraud. We further analyzed a total of 126 cigarette samples, including both original and fraudulent ones, using LDA with a matrix size of (126 × 27). The resulting LDA model demonstrated an accuracy of 98%. Our proposed analytical procedure is characterized by its efficiency, affordability, user-friendliness, and reliability. The selectivity exhibited by the developed sensor array positions it as a valuable tool for differentiating between original and counterfeit cigarettes, thus aiding in border control efforts worldwide.

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Section: Introductionmentioning

confidence: 99%

A Paper-Based Biomimetic Sensing Device for the Discrimination of Original and Fraudulent Cigarette Brands Using Mixtures of MoS2 Quantum Dots and Organic Dyes

2023

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“…17,18 Enoses are made up of an array of cross-reactive receptors whose output signals alter when exposed to the vapor of volatile substances, which can be considered an inexpensive diagnostic method with high sensitivity. 19,20 In addition, these devices are attractive and user-friendly analytical instruments since they are associated with interesting features such as potential of miniaturizing, low cost, and a high degree of selectivity. 21,22 The early E-nose devices worked based on the changing in the resistance of an array of semiconductor materials when exposed to the vapor of VOCs.…”

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confidence: 99%

“…Device Fabrication. An integrated micro-PAD, 19 on which both sample holding zone and sensing zones, were installed, was designed and used in this study. The patterned paper substrate, as illustrated in Figure 1, consists of a hydrophilic central zone with a diameter of 10 mm, serving as the sample holding zone, and 11 smaller hydrophilic zones with a diameter of 3 mm are placed around the sample zone, using for deposition of the sensing reagents' solution.…”

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confidence: 99%

“…If this happens, then the samples come into direct contact with the sensing elements, rendering the optical nose concept ineffective. As previously described, 19 a miniaturized reaction chamber with inside dimension of (3.0 × 3.0 × 0.2, cm) providing a volume of 1.8 mL was created using 3D Max software and then constructed using a 3D printer. The paper-based sensing device is placed into this chamber, and the cap is closed.…”

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confidence: 99%

“…Electronic nose (E-nose) technology, inspired by the mammalian olfactory system, is a unique, simple, and efficient way of detecting and identifying VOCs . These E-nose-based sensors may be utilized to do metabolomic studies. , E-noses are made up of an array of cross-reactive receptors whose output signals alter when exposed to the vapor of volatile substances, which can be considered an inexpensive diagnostic method with high sensitivity. , In addition, these devices are attractive and user-friendly analytical instruments since they are associated with interesting features such as potential of miniaturizing, low cost, and a high degree of selectivity. , …”

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Miniaturized Sniffing Device based on an Array of Fluorescent Carbon Quantum Dots and Metallic Nanoclusters Efficiently Identifies Hematologic Malignancy in Adults

Pesaran,

Khalafinezhad,

Mohammad-Karimi

et al. 2024

Anal. Chem.

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The study demonstrates the potential of an optical nose made by depositing an array of fluorescent nanomaterials on a paper substrate for the early detection of leukemia in adults. This is based on the fact that blood volatile organic compounds (VOCs) are useful leukemia biomarkers. The integrated design was miniaturized and comprised both sensing zones and a sample holding zone, which were installed on a small sheet of paper within a miniature cubic reaction chamber fabricated by using 3D printing technology. The sensing device, comprising seven fluorescent sensing elements, namely, metal nanoclusters, quantum dots, and carbon dots was capable of detecting VOCs in the blood headspace and providing a colorimetric signature that could discriminate between blood samples from healthy and cancerous individuals. A total of 70 new leukemia cases and 51 healthy controls aged 20−50 years were studied. The device required a 60 μL portion of the blood sample and reacted to blood VOCs after 3 h when kept at 50 °C. The imaging data from the device was processed by linear discriminant analysis, and the results confirmed efficient identification of patient samples from healthy samples with 100% accuracy. Overall, the array system is noninvasive (or minimally invasive), portable, fast, inexpensive, and requires only a small amount of blood sample.

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Hydrophobic Paper Used to Construct a Disposable Chemiresistive Immunosensor for the Simultaneous Detection of FB1 and AFB1

He,

Wang,

et al. 2024

Adv Materials Inter

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Co‐contamination of mycotoxins produced by fungi in foodstuffs and feeds causes a tremendous health risk to humans and animals. The simultaneous detection of multiple mycotoxins using a cost‐effective and point‐of‐care technology is key to ensuring food safety. In this study, a disposable biosensor with two individual sensing channels is prepared on an affordable cellulose paper substrate and used to simultaneously detect fumatoxin B1 (FB1) and aflatoxin B1 (AFB1). The biosensor pattern is outlined by polydimethylsiloxane (PDMS) and the hydrophobic interface of the sensing channels is created using octadecyltrichlorosilane (OTS). Semiconducting single‐wall carbon nanotubes (s‐SWCNTs) are deposited onto the central zones to serve as the sensing elements and SWCNTs are deposited into the bilateral areas as wire. After functionalization of the s‐SWCNTs, anti‐FB1 and anti‐AFB1 are separately immobilized on the different sensing regions to capture the targeted mycotoxins. Under the optimal conditions, this developed s‐SWCNTs‐based biosensor array achieved a limit of detection (LOD) of 8.23 pg mL−1 for FB1 and 7.48 pg mL−1 for AFB1. As a demonstration, spiked corn samples are measured using this biosensor and recovery rates are not inferior to commercial enzyme‐linked immune sorbent assay (ELISA) kits. Overall, the cost‐effective, highly sensitive, and multiplexed biosensor platform fabricated by this approach shows great potential for detecting multiple mycotoxins.

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A miniaturized all-in-one optical nose based on 3D printing technology and patterned paper substrate for discrimination of volatile organic compounds

Cited by 9 publications

References 54 publications

A Paper-Based Biomimetic Sensing Device for the Discrimination of Original and Fraudulent Cigarette Brands Using Mixtures of MoS2 Quantum Dots and Organic Dyes

A Paper-Based Biomimetic Sensing Device for the Discrimination of Original and Fraudulent Cigarette Brands Using Mixtures of MoS2 Quantum Dots and Organic Dyes

Miniaturized Sniffing Device based on an Array of Fluorescent Carbon Quantum Dots and Metallic Nanoclusters Efficiently Identifies Hematologic Malignancy in Adults

Hydrophobic Paper Used to Construct a Disposable Chemiresistive Immunosensor for the Simultaneous Detection of FB1 and AFB1

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