A Miniaturized Optofluidic Glucose Monitoring System Based on Enzyme Colorimetry

Xu, Qingmei; Zou, Chongwei; Sun, Chengtao; Zhang, Xingguo; Yu, Haixia; Li, Dachao

doi:10.1109/jsen.2021.3133472

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Besides, abnormal glucose levels in human blood can also give rise to some other diseases. Compared with conventional blood glucose detection techniques such as fluorescence, 2,3 colorimetry 4,5 and gas chromatography, 6 the use of electrochemical sensors is considered as a promising method due to their simple operation, rapid response time, low cost and high detection sensitivity. Their working mechanism is based on the change of current generated by electrochemical oxidation or reduction on the working electrode, and the electrical signal directly reflects the concentration of the analyte.…”

Section: Introductionmentioning

confidence: 99%

Controllable design of a macroporous PBA as an efficient non-enzymatic electrochemical sensor for glucose detection

Ying¹,

Tian²,

Kong³

et al. 2023

CrystEngComm

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Section: Introductionmentioning

confidence: 99%

Controllable design of a macroporous PBA as an efficient non-enzymatic electrochemical sensor for glucose detection

Ying¹,

Tian²,

Kong³

et al. 2023

CrystEngComm

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“…20 However, extraction MNs had some limitations, including limited extraction volume, sample dilution, and multiple detection steps. 21 In situ detection MN, on the other hand, integrated sensing unit (such as colorimetry, fluorescence, and electrochemistry) directly into the MN. This allowed them to encounter and detect analytes in ISF without the need for dilution, thereby enhancing sensitivity and convenience.…”

mentioning

confidence: 99%

“…This allowed them to encounter and detect analytes in ISF without the need for dilution, thereby enhancing sensitivity and convenience. 21 Colorimetric MN, for example, exhibited color changes in response to variations in pH, glucose, protein, uric acid, and temperature, which can be observed with the naked eye. 11,22 Fluorescent MN had been used to monitor changes in inflammatory cytokines in ISF of sepsis mice and assess the effectiveness of a cocaine vaccine.…”

mentioning

confidence: 99%

“…Extraction MN merely extracted ISF and then released the extract in vitro for further biomarker detections via various techniques such as fluorescence and colorimetry . However, extraction MNs had some limitations, including limited extraction volume, sample dilution, and multiple detection steps …”

mentioning

confidence: 99%

“…In situ detection MN, on the other hand, integrated sensing unit (such as colorimetry, fluorescence, and electrochemistry) directly into the MN. This allowed them to encounter and detect analytes in ISF without the need for dilution, thereby enhancing sensitivity and convenience . Colorimetric MN, for example, exhibited color changes in response to variations in pH, glucose, protein, uric acid, and temperature, which can be observed with the naked eye. , Fluorescent MN had been used to monitor changes in inflammatory cytokines in ISF of sepsis mice and assess the effectiveness of a cocaine vaccine. , Electrochemical MN, being popular biosensors, had been combined with wearable devices to detect biomarkers in ISF, such as glucose, lactic acid, and ascorbic acid .…”

mentioning

confidence: 99%

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Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid

Li,

Wang,

Mei

et al. 2024

ACS Sens.

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In vivo drug monitoring is crucial for evaluating the effectiveness and safety of drug treatment. Blood sampling and analysis is the current gold standard but needs professional skills and cannot meet the requirements of point-of-care testing. Dermal interstitial fluid (ISF) showed great potential to replace blood for in vivo drug monitoring; however, the detection was challenging, and the drug distribution behavior in ISF was still unclear until now. In this study, we proposed surface-enhanced Raman spectroscopy (SERS) microneedles (MNs) for the painless and real-time analysis of drugs in ISF after intravenous injection. Using methylene blue (MB) and mitoxantrone (MTO) as model drugs, the innovative core−satellite structured Au@Ag SERS substrate, hydrogel coating over the MNs, rendered sensitive and quantitative drug detection in ISF of mice within 10 min. Based on this technique, the pharmacokinetics of the two drugs in ISF was investigated and compared with those in blood, where the drugs were analyzed via liquid chromatography−mass spectrometry. It was found that the MB concentration in ISF and blood was comparable, whereas the concentration of MTO in ISF was 2−3 orders of magnitude lower than in blood. This work proposed an efficient tool for ISF drug monitoring. More importantly, it experimentally proved that the penetration ratio of blood to ISF was drug-dependent, providing insightful information into the potential of ISF as a blood alternative for in vivo drug detection.

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Proton conduction and electrochemical glucose sensing property of a newly constructed Cu(II) coordination polymer

Gu²,

Shen³

et al. 2023

Journal of Molecular Structure

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A Miniaturized Optofluidic Glucose Monitoring System Based on Enzyme Colorimetry

Cited by 4 publications

References 29 publications

Controllable design of a macroporous PBA as an efficient non-enzymatic electrochemical sensor for glucose detection

Controllable design of a macroporous PBA as an efficient non-enzymatic electrochemical sensor for glucose detection

Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid

Proton conduction and electrochemical glucose sensing property of a newly constructed Cu(II) coordination polymer

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