A minimal algorithm for a minimal recruitment model–model estimation of alveoli opening pressure of an acute respiratory distress syndrome (ARDS) lung

Redmond, Daniel P.; Chiew, Yeong Shiong; Drunen, Erwin J. van; Chase, J. Geoffrey

doi:10.1016/j.bspc.2014.05.006

Cited by 8 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The endotoxin, the activation of the complement, the cytokines, the arachidonic acid's metabolites, liposomal enzymes and kinines, histamine, the nitric oxide or the mediators derived from the endothelium, are the aggressive participants in the decompensation of the patient's clinical status. The complications arise together with micro-embolisms, pulmonary artery hypertension and the alteration of the respiratory functions [41][42][43][44][45][46][47][48]. Neutrophils stimulation through different biochemical mechanisms produces high quantities of hydrogen peroxide [49][50][51].…”

Section: Biochemical Aspects Of Free Radicals and The Actions Of Oxidmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

show abstract

Section: Biochemical Aspects Of Free Radicals and The Actions Of Oxidmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

show abstract

“…Presented below is an outline of RSM for the inflation process [4]. In the model, a total respiratory system is represented by a large population of basic alveolar elements (N = total number of elements) distributed over its (alveolar) opening pressure ], .…”

Section: Summary Of the Previous Workmentioning

confidence: 99%

“…By multiplying the normal distribution of the alveolar elements (= Eq. (2)) by > = _ > , the elemental volume recruited by the pop-open mechanism [4]) and noting > (1 + @> ) with @r = @ / > , the resulting distribution is a recruitment volume distribution expressed as, > . , ], = ∆ 1 + @r .…”

Section: Summary Of the Previous Workmentioning

confidence: 99%

“…Analyses are made on cyclic inflation-deflation loops (to be referred to as tidal loops, simulating artificial ventilation) between a high pressure (Peak) and a low pressure (PEEP (ZEEP) = positive (zero) end-expiratory pressure) along a specified envelope P-V curve of inflation and deflation. There are two modes of small volume tidal loop for ventilation in relation to the main (inflation and deflation) P-V curves [Downie, Nam and Simon [4]]. They are Tidal Loops performed After Inflation from FRC (TLAIFRC) and After Deflation from TLC (TLADTLC) with FRC = functional residual capacity and TLC = total lung capacity.…”

Section: Tidal Loop Analysis : Tlaifrc and Tladtlcmentioning

confidence: 99%

“…In this paper, using a respiratory system model (RSM) [4,5,6], we developed equations for estimating the volume recruitment of respiratory system during mechanical ventilation as functions of respiratory system model parameters as well as the ventilation Positive End Expiratory Pressure (PEEP). The respiratory system model parameters can be obtained by fitting the RSM to the patient's quasi-static pressure-volume curves.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantification of Alveolar Recruitment for the Optimization of Mechanical Ventilation Using Quasi-Static Pressure Volume Curve

Nabian¹,

Narusawa²

2018

Preprint

View full text Add to dashboard Cite

Quasi-static, pulmonary pressure-volume (P-V) curves over an inflation-deflation cycle are analyzed using a respiratory system model (RSM), which had been developed for quantitative characterization of the mechanical behavior of the total respiratory system. Optimum mechanical ventilation setting of Positive End Expiratory Pressure (PEEP) for total alveolar recruitment is quantified based on the existing P-V curves of healthy and injured animal models. Our analytical predictions may contribute to the optimization of mechanical ventilation settings for the Acute Respiratory Distress Syndrome (ARDS) patients.

show abstract

Digital Twins and Automation of Care in the Intensive Care Unit

Chase¹,

Zhou²,

Knopp³

et al. 2023

Cyber–Physical–Human Systems

View full text Add to dashboard Cite

A minimal algorithm for a minimal recruitment model–model estimation of alveoli opening pressure of an acute respiratory distress syndrome (ARDS) lung

Cited by 8 publications

References 13 publications

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Quantification of Alveolar Recruitment for the Optimization of Mechanical Ventilation Using Quasi-Static Pressure Volume Curve

Digital Twins and Automation of Care in the Intensive Care Unit

Contact Info

Product

Resources

About