A Minimally Invasive Blood‐Extraction System: Elastic Self‐Recovery Actuator Integrated with an Ultrahigh‐ Aspect‐Ratio Microneedle

Li, Cheng Guo; Lee, Kwang; Lee, Chang Yeol; Dangol, Manita; Jung, Hyungil

doi:10.1002/adma.201201109

Cited by 45 publications

(31 citation statements)

References 22 publications

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“…As a result, there has been interest in the non-invasive extraction of blood for collection and later testing. Indeed, there are reports of the use of high-aspect ratio MNs for blood extraction [97], [98]. There is also commercial interest in this area (see Table 2).…”

Section: Areas Of Potential Impactmentioning

confidence: 99%

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

Schoellhammer

Blankschtein

Langer³

2014

Expert Opinion on Drug Delivery

307

188

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Introduction Transdermal delivery has potential advantages over other routes of administration. It could reduce first-pass metabolism associated with oral delivery and is less painful than injections. However, the outermost layer of the skin, the stratum corneum (SC), limits passive diffusion to small lipophilic molecules. Therefore, methods are needed to safely permeabilize the SC so that ionic and larger molecules may be delivered transdermally. Areas Covered This review focuses on low-frequency sonophoresis, microneedles, electroporation and iontophoresis, and combinations of these methods to permeabilize the SC. The mechanisms of enhancement and developments in the last five years are discussed. Potentially high-impact applications, including protein delivery, vaccination, and sensing, are presented. Finally, commercial interest and clinical trials are discussed. Expert Opinion Not all permeabilization methods are appropriate for all applications. Focused studies into applications utilizing the advantages of each method are needed. The total dose and kinetics of delivery must be considered. Vaccination is one application where permeabilization methods could make an impact. Protein delivery and analyte sensing are also areas of potential impact, although the amount of material that can be delivered (or extracted) is of critical importance. Additional work on the miniaturization of these technologies will help to increase commercial interest.

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Section: Areas Of Potential Impactmentioning

confidence: 99%

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

Schoellhammer

Blankschtein

Langer³

2014

Expert Opinion on Drug Delivery

307

188

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“…In this study, we develop a point-of-care testing (POCT) device using a microneedle [14], a flow-through-hole (FTH) thin multilayer film, a 3D electrochemical immune biosensor [15], and highly sensitive signal processing circuitry.…”

Section: Ami Detection Devicementioning

confidence: 99%

“…finger, the needle penetrates the patient's skin and approximately 20 μl of blood is extracted through an internal vacuum effect. The pressed state must be maintained for 10 s [14]. The electrochemical immune biosensor can detect four types of cardiac markers.…”

Section: Ami Detection Devicementioning

confidence: 99%

A smartphone‐based U‐Healthcare system for real‐time monitoring of acute myocardial infarction

Jung

Lee

et al. 2015

Int J Communication

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In recent years, medical service has been evolving from systems designed around centralized hospitals to Ubiquitous Healthcare (U-Healthcare). U-Healthcare system can facilitate real-time monitoring of patient states, and can provide medical checkups and management whenever and wherever the medical staff deems necessary. U-Healthcare services can provide chronic condition monitoring in the early stages of diseases and help execute decisive medical action in emergencies. However, thus far, the application of U-Healthcare systems has been limited to diseases such as obesity, diabetes, etc. Acute myocardial infarction (AMI) is among the most critical chronic diseases and requires early detection and treatment. In this paper, we propose an AMI diagnostic software technique and protocol that can support real-time communication between the patient and medical personnel. Our monitoring and diagnostic system has been developed using a protocol based on ISO/IEEE 11073. When data is transferred from the patient's smartphone to a server in hospital, the medical personnel consult the patient's biosensor data to determine the status of the relevant disease and provide appropriate medical service. The relevant information is sent back to the patient's smartphone through a wireless network, and patients can view their data in graphical format through their smartphone. Figure 3 shows the network structure of our proposed AMI U-Healthcare system. We apply the following technologies in the AMI detection system: (i) A microneedle for blood sample extraction [23], (ii) a flow-through hole layer and a microfluidic layer to separate serum in the blood sample, (iii) three-dimensional (3D) bio-electrical sensors to detect AMI cardiac markers (cardiac troponin T (cTnT) and I (cTnI), creatine kinase MB (CK-MB) isoenzyme, and myoglobin), and (iv) signal processing circuits [24,25]. A smartphone is an ideal device for U-Healthcare communication for the following reasons: (i) Most people tend to keep their smartphone within an accessible distance; (ii) one can use smartphones to communicate practically anywhere, and (iii) smartphones are sufficiently powerful to perform a number of complex tasks.We designed an Android-based application to control our AMI detection device and collect AMI cardiac marker data. This application enables a patient, or a hospital that needs a patient's medical information, to review their personal information, AMI prognostic information, and information regarding the relevant medical personnel. The patient's cardiac marker data, along with their personal information and diagnostic history, are stored on a server. The data is accessed by medical personnel using a client software [26]. The application transmits the patient's cardiac marker data to a hospital server over third-generation (3G) or Wi-Fi infrastructure [27]. The AMI Detection Device is equipped with three sets of replaceable cardiac marker detection sensors [25,28]. Cardiac marker data measured by these sensors can be transferred to a server at any sched...

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“…One method for sampling the ISF or blood relies on capillary action, which requires the needle lumens to contain hydrophilic surfaces [2]. Another method for sampling ISF or blood is applying a low pressure through the microneedle lumens [8].…”

Section: Introductionmentioning

confidence: 99%

Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures

Mansoor

Liu

Häfeli

et al. 2013

J. Micromech. Microeng.

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Transdermal drug delivery using microneedles is a technique to potentially replace hypodermic needles for injection of many vaccines and drugs. Fabrication of hollow metallic microneedles so far has been associated with time-consuming steps that restrict batch production of these devices. Here, we are presenting a novel method for making metallic microneedles with any desired height, spacing, and lumen size. In our process, we use solvent casting to coat a mold, which contains an array of pillars, with a conductive polymer composite layer. The conductive layer is then used as a seed layer in a metal electrodeposition process. To characterize the process, the conductivity of the polymer composite with respect to different filler concentrations was investigated. In addition, plasma etching of the polymer was characterized. The electroplating process was also studied further to control the thickness of the microneedle array plate. The strength of the microneedle devices was evaluated through a series of compression tests, while their performance for transdermal drug delivery was tested by injection of 2.28 μm fluorescent microspheres into animal skin. The fabricated metallic microneedles seem appropriate for subcutaneous delivery of drugs and microspheres.

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A Minimally Invasive Blood‐Extraction System: Elastic Self‐Recovery Actuator Integrated with an Ultrahigh‐ Aspect‐Ratio Microneedle

Cited by 45 publications

References 22 publications

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

A smartphone‐based U‐Healthcare system for real‐time monitoring of acute myocardial infarction

Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures

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