A minimized fluorescent chemosensor array utilizing carboxylate-attached polythiophenes on a chip for metal ions detection

Sasaki, Yoko; Lyu, Xiaojun; Zhang, Zhoujie; Minami, Tsuyoshi

doi:10.1007/s11705-021-2037-y

Cited by 15 publications

(6 citation statements)

References 55 publications

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“…Subsequently, AGE classification or profiling is demonstrated by utilizing AGE-specific Apts incorporated with PTs that contain different pendant groups. PTs with varying pendant groups (acidic and basic functional groups) could be utilized to develop chemosensor arrays. − Herein, PTs with four different pendant groups, PT1–PT4, are incorporated with four different Apts, Apt1–Apt4, for assaying four different AGEs (AGE classes): AGE1, glucose-derived AGEs (AGE2), methylglyoxal-derived AGEs (AGE3), and carboxymethyllysine-derived AGEs (AGE4) (explained in detail in the Supporting Information). It is hypothesized that different terminal groups could modulate the interring twisting of PTs upon complexation with Apts and AGEs, thereby yielding varying optical responses.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric and Fluorometric Profiling of Advanced Glycation End Products

Ammanath

Delachi

Karabacak

et al. 2021

ACS Appl. Mater. Interfaces

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Profiling of advanced glycation end products (AGEs) is an emerging area of clinical significance for disease diagnosis and prognosis. Typically, concentrations of AGEs are estimated in laboratories by trained personnel using sophisticated equipment. Herein, a facile approach for colorimetric and fluorometric profiling of AGEs is reported for rapid and on-site analysis. The concentrations of AGE levels in plasma are estimated via changes in optical properties of polythiophenes (PTs) upon interaction with aptamers (Apts) in the presence and in the absence of AGEs. To validate the proposed approach, glyceraldehyde-derived AGEs (AGE class 1 [AGE1]), the biomarker associated with cardiovascular diseases and diabetes, are used as a model system. Colorimetric analysis yielded linear responses for AGE1 for clinically relevant concentration ranges between 1.5 and 300 μg/mL with a limit of detection (LOD) of ∼1.3 μg/mL. Subsequently, an approach utilizing PTs with four different pendant groups in conjunction with four different Apts is demonstrated for qualitative colorimetric profiling and for quantitative fluorometric profiling of up to four AGEs in clinical matrices. Principal component analysis (PCA) of fluorometric responses of AGE-spiked samples yielded distinct responses for the different AGEs tested. Thus, the proposed approach ascertains rapid profiling of spiked AGEs in plasma samples without the requirement of preanalytical processing and advanced instrumentation, thereby facilitating on-site diagnosis.

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Section: Introductionmentioning

confidence: 99%

Colorimetric and Fluorometric Profiling of Advanced Glycation End Products

Ammanath

Delachi

Karabacak

et al. 2021

ACS Appl. Mater. Interfaces

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“…In contrast to phthalate, isophthalate and terephthalate, which possess carboxy groups at the 1,3‐ and 1,4‐positions, respectively, could form random aggregation through multiple non‐covalent interactions [8i] . Certainly, the increase in baselines without blueshifts ( i. e ., Rayleigh scattering) [8i,k,q] was observed by adding excess amounts of isophthalate (>250 μM) and terephthalate (>300 μM). Different response orders for oxalate, glyphosate, phthalate, and H 2 PO 4 − were also observed in the colorimetric and fluorescence profiles.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In aggregation‐driven chemical sensing, the π‐stacking among polymer wires is accelerated by backbone‐planarization of π‐conjugated polymers upon the addition of analytes [8h,i,p,q] . The formation of π‐stacked aggregates causes drastic optical changes, such as redshifts in the UV‐vis absorption spectra and turn‐off‐type fluorescence responses, allowing naked‐eye detection [8h,i,p,q] . Aggregation‐driven PT sensors have been applied to high‐throughput sensing using pattern recognition techniques, [8e–h,p,q] whereas this sensing mechanism cannot avoid precipitation derived from dominant polymer aggregation.…”

Section: Introductionmentioning

confidence: 99%

“…The formation of π‐stacked aggregates causes drastic optical changes, such as redshifts in the UV‐vis absorption spectra and turn‐off‐type fluorescence responses, allowing naked‐eye detection [8h,i,p,q] . Aggregation‐driven PT sensors have been applied to high‐throughput sensing using pattern recognition techniques, [8e–h,p,q] whereas this sensing mechanism cannot avoid precipitation derived from dominant polymer aggregation. Hence, time‐dependent optical changes accompanied by precipitation are unsuitable for quantitative detection.…”

Section: Introductionmentioning

confidence: 99%

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Zn(II)‐Dipicolylamine‐Attached Amphiphilic Polythiophene for Quantitative Pattern Recognition of Oxyanions in Mixtures

Sasaki

Ohshiro

Okabe

et al. 2023

Chemistry An Asian Journal

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Herein, we propose a novel amphiphilic polythiophene‐based chemosensor functionalized with a Zn(II)‐dipicolylamine side chain (1poly ⋅ Zn) for the pattern recognition of oxyanions. Optical changes in amphiphilic 1poly ⋅ Zn can be induced by the formation of a random coil from a backbone‐planarized structure upon the addition of target oxyanions, which results in blueshifts in the UV‐vis absorption spectra and turn‐on‐type fluorescence responses. Dynamic behavior in a polythiophene wire and/or among wires could be a driving force for obtaining visible color changes, while the molecular wire effect is dominant in obtaining fluorescence sensor responses. Notably, the magnitude of optical changes in 1poly ⋅ Zn has depended on differences in properties of oxyanions, such as their binding affinity, hydrophilicity, and molecular geometry. Thus, various colorimetric and fluorescence response patterns of 1poly ⋅ Zn to oxyanions were obtained, albeit using a single chemosensor. A constructed information‐rich dataset was applied to pattern recognition for the simultaneous group categorization of phosphate and carboxylate groups and the prediction of similar structural oxyanions at a different order of concentrations in their mixture solutions.

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A Sensor Array for the Ultrasensitive Discrimination of Heavy Metal Pollutants in Seawater

Ihde

Tropp

Díaz

et al. 2022

Adv Funct Materials

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Metal cations are potent environmental pollutants that negatively impact human health and the environment. Despite advancements in sensor design, the simultaneous detection and discrimination of multiple heavy metals at sub‐nanomolar concentrations in complex analytical matrices remain a major technological challenge. Here, the design, synthesis, and analytical performance of three highly emissive conjugated polyelectrolytes (CPEs) functionalized with strong iminodiacetate and iminodipropionate metal chelates that operate in challenging environmental samples such as seawater are demonstrated. When coupled with array‐based sensing methods, these polymeric sensors discriminate among nine divalent metal cations (CuII, CoII, NiII, MnII, FeII, ZnII, CdII, HgII, and PbII). The unusually high and robust luminescence of these CPEs enables unprecedented sensitivity at picomolar concentrations in water. Unlike previous array‐based sensors for heavy metals using CPEs, the incorporation of distinct π‐spacer units within the polymer backbone affords more pronounced differences in each polymer's spectroscopic behavior upon interaction with each metal, ultimately producing better analytical information and improved differentiation. To demonstrate the environmental and biological utility, a simple two‐component sensing array is showcased that can differentiate nine metal cation species down to 500 × 10−12 m in aqueous media and to 100 × 10−9 m in seawater samples collected from the Gulf of Mexico.

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A minimized fluorescent chemosensor array utilizing carboxylate-attached polythiophenes on a chip for metal ions detection

Cited by 15 publications

References 55 publications

Colorimetric and Fluorometric Profiling of Advanced Glycation End Products

Colorimetric and Fluorometric Profiling of Advanced Glycation End Products

Zn(II)‐Dipicolylamine‐Attached Amphiphilic Polythiophene for Quantitative Pattern Recognition of Oxyanions in Mixtures

A Sensor Array for the Ultrasensitive Discrimination of Heavy Metal Pollutants in Seawater

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