A minireview on phytochemical and medicinal properties of Clinacanthus nutans

Lin, Teoh Peik

doi:10.7324/japs.2021.110602

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…In fact, there are a number of phytocompounds identified in C. nutans, such as lupeol, stigmasterol, β-sitosterol, betulin and myricyl alcohol [46]. Other than this, there are six known C-glycosyl flavones, including orientin, isoorientin, isomollupentin 7-O-β-Dglucopyranoside, schaftoside, isovitexin and vitexin, that were isolated from the butanol and water extracts of this plant [47]. Sulfur-containing glucosides, such as clinacoside A, clinacoside B, clinacoside C and cycloclinacoside A1, were also detected in the butanol fraction [48].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

Tan²,

Bok³

et al. 2022

Molecules

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Antioxidants are currently utilized to prevent the occurrence of liver cancer in non-alcoholic fatty liver disease (NAFLD) patients. Clinacanthus nutans possesses anti-oxidative and anti-inflammatory properties that could be an ideal therapy for liver problems. The objective of this study is to determine the potential antioxidative compounds from the C. nutans leaves (CNL) and stems (CNS). Chemical- and cell-based antioxidative assays were utilized to evaluate the bioactivities of CNS and CNL. The NMR metabolomics approach assisted in the identification of contributing phytocompounds. Based on DPPH and ABTS radical scavenging activities, CNL demonstrated stronger radical scavenging potential as compared to CNS. The leaf extract also recorded slightly higher reducing power properties. A HepG2 cell model system was used to investigate the ROS reduction potential of these extracts. It was shown that cells treated with CNL and CNS reduced innate ROS levels as compared to untreated controls. Interestingly, cells pre-treated with both extracts were also able to decrease ROS levels in cells induced with oxidative stress. CNL was again the better antioxidant. According to multivariate data analysis of the 1H NMR results, the main metabolites postulated to contribute to the antioxidant and hepatoprotective abilities of leaves were clinacoside B, clinacoside C and isoschaftoside, which warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

Tan²,

Bok³

et al. 2022

Molecules

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“…When a leaf is young, its surface is pubescent; as it becomes older, however, it turns glabrescent. At the top of branchlets and branches, yellowish blooms proliferate in clusters [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition of Clinacanthus nutans based on factors of environment, genetics and postharvest processes: A review

Sabindo,

Yatim,

Ponnuraj

2024

BioMedicine

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Herpes simplex , varicella-zoster lesions, skin rashes, diabetes, snake bites and insect bites have all been treated by using Clinacanthus nutans ( C. nutans ). The pharmacological effects of C. nutans are influenced by the presence of terpenoids, flavonoids, alkaloids, phenolic acids, saponins, glycosides, steroids and tannins. This review focused on the phytochemical makeup, which varies geographically and is a subject of scarcely existing knowledge. C. nutans served as the primary search term, while the keywords “phytochemicals”, “chemical component” and “phytochemistry” were used to search the literature in the Google Scholar, PubMed, Scopus and Web of Science databases. The articles pertinent to the subject were found and reviewed. The phytochemical composition of C. nutans varied depending on the region it was cultivated in, and was influenced by the environmental conditions, genetics, air temperature and postharvest practices.

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Fabrication and Characterization of Clinacanthus nutans Mediated Reduced Graphene Oxide Using a Green Approach

et al. 2022

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The reduction of graphene oxide (rGO) utilizing green methods such as plants has attracted much attention due to its productivity, eco—friendly features, and cost effectiveness. In the present study, the reflux method was employed to synthesize Clinacanthus nutans (C. nutans) leaf extract mediated rGO using a simple approach. The synthesized rGO was characterized using various spectroscopic and microscopic techniques. The UV-Vis spectrum demonstrated the absorption peak of rGO (270 nm) at distinct locations, while the FTIR analysis demonstrated that the amount of oxygen group in rGO was reduced. The Raman analysis confirms the reduction of GO by a slight increase in the D—band to G—band intensity ratio. The XRD spectra demonstrated that rGO was successfully produced based on the illustrated 2Ɵ angles at a peak of 22.12° with d-spacing of 0.40 nm. FESEM clearly reveals the morphology of rGO that shows crumpled thin sheets, a rougher surface, and a wave—shaped corrugated structure. The reduction of GO was analyzed in the removal of the hydroxyl group and amorphotization of sp2 carbon structures. The C/O ratio in rGO was higher than GO which indicates the small amount of oxygen-containing functional groups were still presented in the reduced graphene oxide. Furthermore, the cyclic voltammetry behavior of a modified screen—printed carbon electrode (SPCE) was measured. The redox reactivity of rGO—SPCE has been affirmed and compared with GO—SPCE and bare—SPCE. The toxicity using A. salina cysts demonstrated that rGO is less toxic compared to GO. The analysis adequately supports the synthesis of rGO and the effective removal of oxygen-containing functional groups from GO. The findings herein illustrate that C. nutans mediates the synthesis of rGO and is a promising eco-friendly substitute to conventional carbon-based fabrication.

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A minireview on phytochemical and medicinal properties of Clinacanthus nutans

Cited by 3 publications

References 37 publications

Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

Phytochemical composition of Clinacanthus nutans based on factors of environment, genetics and postharvest processes: A review

Fabrication and Characterization of Clinacanthus nutans Mediated Reduced Graphene Oxide Using a Green Approach

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