A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers
Anna Barbato,
Fabiola Piscopo,
Massimiliano Salati
et al.
Abstract:Despite recent advances, biliary tract cancer (BTC) remains one of the most lethal tumor worldwide due to late diagnosis, limited therapeutic strategies and resistance to conventional therapies. In recent years, high-throughput technologies have enabled extensive genome, and transcriptome sequencing unveiling, among others, the regulatory potential of microRNAs (miRNAs). Compelling evidence shown that miRNA are attractive therapeutic targets and promising candidates as biomarkers for various therapy-resistant … Show more
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