2011
DOI: 10.4174/jkss.2011.81.5.308
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A missense polymorphism (rs11895564, Ala380Thr) of integrin alpha 6 is associated with the development and progression of papillary thyroid carcinoma in Korean population

Abstract: PurposeIntegrins play crucial roles in the pathogenesis of papillary thyroid carcinoma (PTC). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNPs) (rs2141698, -1687A/G; rs11895564, Ala380Thr) of the integrin alpha 6 (ITGA6) gene are associated with the development and clinicopathologic characteristics of PTC such as the size (<1 cm and ≥1 cm), number (unifocality and multifocality), location (one lobe and both lobes), extrathyroid invasion, and cervical lymph node metasta… Show more

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Cited by 9 publications
(7 citation statements)
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“…For example, integrin α6 has been reported to mediate progression of papillary thyroid cancer [38]. Therefore, we further evaluated the protein levels of FN receptors such as integrins α6, β1, and β3 in thyroid tumors of LFD- or HFD- Thrb PV/PV Pten +/− mice.…”
Section: Resultsmentioning
confidence: 99%
“…For example, integrin α6 has been reported to mediate progression of papillary thyroid cancer [38]. Therefore, we further evaluated the protein levels of FN receptors such as integrins α6, β1, and β3 in thyroid tumors of LFD- or HFD- Thrb PV/PV Pten +/− mice.…”
Section: Resultsmentioning
confidence: 99%
“…In cancer, integrins are deregulated in part by enhanced transcription induced by oncogenes, alterations in the chromatin structure, overexpression of growth factors and growth factor receptors or changes in the ECM. The indispensable role of integrins in carcinogenesis is also exposed by the fact that integrin single-nucleotide polymorphisms (SNP) seem to have a great impact in tumor agressiveness, survival and suceptibility to thrombus formation in cancer [209,210,211,212]. It is, therefore, unquestionable that integrins are promising targets for cancer treatment.…”
Section: Hotspots For Anticancer Treatmentmentioning
confidence: 99%
“…Previous studies have found an association between the ITGα6 (380Thr, rs11895564) SNP and papillary thyroid carcinoma and intra-cerebral hemorrhage development [22,23]. …”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, a high frequency of the α6 subunit A380T polymorphism (rs11895564) has been observed in papillary thyroid carcinoma. A380T was mainly associated with the size, number and tumor lymphatic metastasis [22]. …”
Section: Introductionmentioning
confidence: 99%