This technical report discusses recent advances in electronic prescribing (e-prescribing) systems, including the evidence base supporting their limitations and potential benefits. Specifically, this report acknowledges that there are limited but positive pediatric data supporting the role of e-prescribing in mitigating medication errors, improving communication with dispensing pharmacists, and improving medication adherence. On the basis of these data and on the basis of federal statutes that provide incentives for the use of e-prescribing systems, the American Academy of Pediatrics recommends the adoption of e-prescribing systems with pediatric functionality. This report supports the accompanying policy statement from the American Academy of Pediatrics recommending the adoption of e-prescribing by pediatric health care providers. Pediatrics 2013;131:e1350-e1356The US health care system has the distinction of being the world' s most expensive delivery system while also having among the lowest levels of quality, as judged by many metrics, including infant mortality, life expectancy, and potential years of life lost. 1,2 More specifically, despite US leadership in establishing many standards of care that correlate with improved quality, the US health care system is able to deliver, at best, 60% of the recommended care in most practices. 3,4 Reasons for this inefficiency include the voluminous information resources to consult and the experts' parallel processing and modeling skills (including integrating considerations of the patient' s other illnesses, lifestyle, and genome) required to make an optimal decision. 5 Other challenges include the health care system' s existing methods of payment, which lead to fragmented care. 6 Difficult-to-resolve health disparities also occur when there are suboptimal interactions between a person' s preferences, the regulatory/operational health care system, and internalized biases, stereotypes, or knowledge deficits. All of these challenges to information management affect the delivery of care. 7 For these reasons, health information technology (HIT) has become recognized as a set of tools that complement the provision of care. 8 Electronic prescribing (e-prescribing) is widely recognized as a component of the prescribing process that facilitates handoffs, improves clinical decision-making, and may improve medication adherence. E-prescribing was defined in 2008 by the Centers for Medicare and Medicaid Services as a system providing prescribers with