How do people cope with spiritual struggles? For those who believe in a personal, relational God, some responses may focus on their perceived relationship with God: They might approach (draw close), disengage (turn away or exit), protest (complain, argue, or question), or suppress (avoid or minimize negative feelings). This paper presents initial validation data for the 18-item Behaviors Toward God Scale (BTGS-18), a self-report measure designed to assesses approach, disengagement, protest, and suppression responses toward God in the context of religious/spiritual (r/s) struggle. Drawing from an Internet sample of 2,889 U.S. adults reporting r/s struggles, we randomly divided the sample into Group 1 (N = 1,445) for structural analyses and Group 2 (N = 1,444) for initial validity tests. Primary hypotheses were preregistered. Group 1 analyses, including an exploratory structural equation model, confirmatory factor analysis, and several invariance tests, suggested strong support for a four-factor model with subscales that can be scored by averaging across items. In Group 2, correlations and regressions provided reasonable preliminary evidence of validity (especially convergent validity) for the four BTGS-18 subscales by examining their associations with religious belief salience, God concept, positive attitudes and anger toward God, religious coping, spiritual growth and decline, and emotional distress (anxiety, depression, and anger/hostility). Due to overlap between the BTGS-18 subscales, regression is recommended to examine unique contributions of each subscale. In addition, protest, suppression, and especially disengagement correlated negatively with social desirability, suggesting that it may be wise to control social desirability in future studies.