A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle1,2

Abell, Kaitlynn M.; Theurer, Miles E.; Larson, Robert L.; White, Bradley J.; Apley, Michael D.

doi:10.2527/jas.2016.1062

Cited by 36 publications

(37 citation statements)

References 41 publications

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“…Numerous studies have been done comparing efficacy of metaphylactic administration of tulathromycin to other antimicrobials in the control of BRD in feedlot cattle; however, there is very limited data that pertains to stocker cattle (Godinho et al, 2005;Skogerboe et al, 2005;Booker et al, 2007;Tennant et al, 2014). The results of our study are consistent with the work of others showing that tulathromycin is superior to other antimicrobials for controlling BRD (Skogerboe et al, 2005;Booker et al, 2007;Van Donkersgoed et al, 2008;Tennant et al, 2014;Abell et al, 2017). Significantly, fewer calves that received tulathromycin required 1 treatment for BRD during the first 45 d after arrival.…”

Section: Discussionsupporting

confidence: 88%

“…Although multiple antimicrobials are labeled for metaphylaxis, tulathromycin is one of the most frequently used compounds currently available. A recent mixed treatment meta-analysis comparing efficacy of antimicrobials commonly used for metaphylaxis in cattle populations found that tulathromycin was superior to many of the other antimicrobials (ceftiofur, oxytetracycline, florfenicol, trimethoprim-sulfamethoxazole) evaluated for reducing BRD morbidity in the first 60 d on feed (Abell et al, 2017). Unfortunately, studies have shown a high prevalence of shedding of MDR M. haemolytica in stocker cattle following metaphylaxis with tulathromycin (Snyder et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Comparative efficacy of enrofloxacin to that of tulathromycin for the control of bovine respiratory disease and prevalence of antimicrobial resistance in Mannheimia haemolytica in calves at high risk of developing bovine respiratory disease1

Crosby

Credille

Giguère

et al. 2018

Journal of Animal Science

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Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. Mannheimia haemolytica is the bacterial pathogen most often isolated from cattle with BRD, and the prevalence of antimicrobial resistance (AMR) in this organism has increased in recent years. Antimicrobials are commonly used to prevent BRD in cattle at high risk of developing BRD; however, recent work would suggest that this practice might be one factor contributing to the increased prevalence of AMR in M. haemolytica. We hypothesized that the administration of the short-acting fluoroquinolone, enrofloxacin, would be just as effective as the long-acting triamilide, tulathromycin, in preventing BRD but would be less likely to select for AMR M. haemolytica in stocker calves at high risk of developing BRD. Three hundred forty-one stocker calves were enrolled in the study with 172 calves in 4 pens being randomly assigned to treatment with enrofloxacin and 169 calves in 4 pens randomly assigned to treatment with tulathromycin. Calves within each treatment group were allocated to one of 4 replicate pens based on the week of enrollment. Of calves receiving enrofloxacin, 33.7% required treatment for BRD at least once within 45 d after arrival, compared with 18.3% of calves receiving tulathromycin (P = 0.040). The percentages of calves that required more than one treatment for BRD within 45 d after arrival did not differ statistically for those receiving enrofloxacin compared with those receiving tulathromycin (10.5% and 4.7%, respectively; P = 0.107) Likewise, the percentages of calves that died during the 45-d follow-up period did not differ for those receiving enrofloxacin compared with those receiving tulathromycin (12.2% and 10.1%, respectively; P = 0.592). Mannheimia haemolytica was cultured from 11% of calves sampled at arrival and from 50% of calves sampled at revaccination 14 to 17 d later. There was a significanst effect of sampling time on the proportion of calves carrying multidrug-resistant (MDR) isolates, with calves having a higher prevalence of MDR isolates at revaccination than arrival (100% vs. 13%; P < 0.001). Future research evaluating the impact of MDR on response to antimicrobial therapy is necessary.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of enrofloxacin to that of tulathromycin for the control of bovine respiratory disease and prevalence of antimicrobial resistance in Mannheimia haemolytica in calves at high risk of developing bovine respiratory disease1

Crosby

Credille

Giguère

et al. 2018

Journal of Animal Science

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“…Because groups of cattle that are deemed to have an especially high risk of BRD can already be incubating infections that will become life-threatening despite the absence of clinical signs, groups of cattle with particularly high risk of BRD are sometimes treated with antimicrobial drugs (AMDs) at the time they enter feedlots, a practice that is known as metaphylaxis. Metaphylactic treatment of entire groups of cattle with a high risk of BRD can be highly efficacious in preventing life-threatening disease; specifically, parenteral administration of therapeutic doses of tulathromycin has been shown to be highly effective when used as metaphylaxis for preventing illness and death related to BRD (Wellman and O'Connor, 2007 ; Murray et al, 2016 ; O'Connor et al, 2016 ; Abell et al, 2017 ). However, treatment of animals with AMDs, especially mass treatment regimens, are subject to increasing concern and scrutiny because of the potential for public health impacts related to antimicrobial resistance in bacteria that may be transferred to consumers through the food chain or environmental routes.…”

Section: Introductionmentioning

confidence: 99%

“…In the most recent national survey data available, 45.3% of feedlots reporting metaphylaxis use reported using tulathromycin to prevent BRD when cattle arrived at the feedlot (USDA, 2013 ). Its use has been demonstrated to be highly effective in reducing BRD morbidity in feedlot cattle with only minor adverse side-effects (Modric et al, 2011 ; Abell et al, 2017 ), but cardiotoxicity has been reported in several species such as mice and rabbits (Er et al, 2011 ; Abdel-Daim et al, 2018 ). Tulathromycin is a macrolide, a class of antimicrobials considered critically important for human medicine (World Health Organization, 2011 ) and despite increasing scrutiny of antimicrobial use practices in livestock production, little work has been performed to study the effect of tulathromycin metaphylaxis on antimicrobial resistance (AMR) in cattle.…”

Section: Introductionmentioning

confidence: 99%

Investigating Effects of Tulathromycin Metaphylaxis on the Fecal Resistome and Microbiome of Commercial Feedlot Cattle Early in the Feeding Period

et al. 2018

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The objective was to examine effects of treating commercial beef feedlot cattle with therapeutic doses of tulathromycin, a macrolide antimicrobial drug, on changes in the fecal resistome and microbiome using shotgun metagenomic sequencing. Two pens of cattle were used, with all cattle in one pen receiving metaphylaxis treatment (800 mg subcutaneous tulathromycin) at arrival to the feedlot, and all cattle in the other pen remaining unexposed to parenteral antibiotics throughout the study period. Fecal samples were collected from 15 selected cattle in each group just prior to treatment (Day 1), and again 11 days later (Day 11). Shotgun sequencing was performed on isolated metagenomic DNA, and reads were aligned to a resistance and a taxonomic database to identify alignments to antimicrobial resistance (AMR) gene accessions and microbiome content. Overall, we identified AMR genes accessions encompassing 9 classes of AMR drugs and encoding 24 unique AMR mechanisms. Statistical analysis was used to identify differences in the resistome and microbiome between the untreated and treated groups at both timepoints, as well as over time. Based on composition and ordination analyses, the resistome and microbiome were not significantly different between the two groups on Day 1 or on Day 11. However, both the resistome and microbiome changed significantly between these two sampling dates. These results indicate that the transition into the feedlot—and associated changes in diet, geography, conspecific exposure, and environment—may exert a greater influence over the fecal resistome and microbiome of feedlot cattle than common metaphylactic antimicrobial drug treatment.

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“…Transportation increases disease susceptibility of calves ( 15 ) and performing preventive interventions before transportation is associated with enhanced health and performance after transportation ( 16 ). However, vaccinations and metaphylaxis are often performed after transportation ( 17 ). Treating dairy calves after the disease is diagnosed does not eliminate the negative effects on long-term production and the metaphylactic use of antimicrobials can contribute to the alleged influence of animal agriculture on the selection of antimicrobial resistance genes ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Administration of a Non-specific Immune Stimulant Around Transportation on Health and Performance of Jersey and Jersey-Cross Heifer Calves During the Rearing Period: Randomized Clinical Trial

et al. 2020

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Our objective was to evaluate the effects of a non-specific immune stimulant (IS) administered around transportation on health scores (HS), average daily gain (ADG), disease treatment and mortality of Jersey and Jersey-cross calves during the rearing period. Newborn calves (4 d ± 1) were randomly allocated to receive either 1 mL of saline (CON; n = 438), 1 mL of IS before transport (BTIS; n = 431), or 1 mL of IS immediately after transport (ATIS; n = 436). Calves were health scored weekly for 3 weeks after transport. The data were analyzed using multivariable linear mixed models and multivariable logistic regression models. Kaplan-Meier survival analysis was performed for time to event analysis. Treatment, birth weight, breed, site of birth, serum total solids, dam parity, season of enrollment, and metaphylaxis were offered to models. Differences in respiratory and fecal HS, and ADG between treatment groups were not statistically significant. A total of 196 (15.0%) calves were treated at least once for any disease and 52 calves were treated multiple times. The proportion of calves treated for respiratory disease and/or diarrhea were 14.4, 14.4, and 16.2% for BTIS, ATIS and CON groups, respectively. Although the differences in the likelihood of treatment for both respiratory disease and/or diarrhea during the first 9 weeks of life was not statistically different between groups, we observed that more calves in the control group received disease treatments around 15 days of age compared with calves that received IS. The likelihood of treatment for respiratory diseases alone during the first 30 days of life was smaller in the calves that received IS before transportation when compared to the control group. Only 18 (1.4%) calves died within the study period. The calf mortality likelihood was not statistically different between study groups; however, fewer calves in the IS groups died when compared to CON. In conclusion, the use of IS around transportation did not influence weekly HS, ADG, and the number of disease treatments during the rearing period, but administering IS before transportation resulted in fewer treatments of respiratory diseases during the first 30 days post-transport and marginally lower mortality rates during the rearing period.

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A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle1,2

Cited by 36 publications

References 41 publications

Comparative efficacy of enrofloxacin to that of tulathromycin for the control of bovine respiratory disease and prevalence of antimicrobial resistance in Mannheimia haemolytica in calves at high risk of developing bovine respiratory disease1

Comparative efficacy of enrofloxacin to that of tulathromycin for the control of bovine respiratory disease and prevalence of antimicrobial resistance in Mannheimia haemolytica in calves at high risk of developing bovine respiratory disease1

Investigating Effects of Tulathromycin Metaphylaxis on the Fecal Resistome and Microbiome of Commercial Feedlot Cattle Early in the Feeding Period

Effects of the Administration of a Non-specific Immune Stimulant Around Transportation on Health and Performance of Jersey and Jersey-Cross Heifer Calves During the Rearing Period: Randomized Clinical Trial

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