A mixture of five endocrine-disrupting chemicals modulates concentrations of bisphenol A and estradiol in mice

Pollock, Tyler; Weaver, Rachel E.; Ghasemi, Ramtin; deCatanzaro, Denys

doi:10.1016/j.chemosphere.2017.11.030

Cited by 34 publications

(17 citation statements)

References 76 publications

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“…We verified this result in both mice and KGN cells and found that PP could interfere with estradiol secretion. This is in agreement with findings of other studies that reported that PP exposure can increase estradiol levels in cultured mouse antral follicles, mouse urine, and MCF‐7 breast cancer cells (Gal et al, 2019; Pollock et al, 2018; Wróbel & Gregoraszczuk, 2013).…”

Section: Discussionsupporting

confidence: 92%

Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro

Jiao

Zhai

et al. 2021

J of Applied Toxicology

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Female reproduction is precisely regulated by hormones, and the ovary is easily affected by environmental endocrine disruptors (EDCs), which are ubiquitous in industrialized societies. Parabens are EDCs that are used as antibacterial preservatives in cosmetics, personal care products (PCPs), medicines, and food. We used ultrahigh‐performance liquid chromatography–mass spectrometry to quantitatively detect methyl‐, ethyl‐, butyl‐, and propylparaben (PP) concentrations in urine samples from 74 women of childbearing age. Balb/c mice were subcutaneously injected with 100 mg/kg/day of PP for 21 consecutive days or 100 or 1,000 mg/kg/day of PP during superovulation. Various concentrations of PP (ranging from 1 to 1,000 nM) were added to a human ovarian granulosa tumor‐derived cell line (KGN) culture for 24 h. The urinary paraben concentrations of women who used cosmetics and other PCPs within 48 h prior to sample collection were significantly elevated, and the PP concentration was significantly positively correlated with the basal estradiol concentration. After PP injection, the mouse serum estradiol concentrations were significantly increased, estrus cycles were disordered, corpus luteum number was reduced, and number of oocytes retrieved was significantly reduced. In in vitro experiments, PP treatment increased estradiol synthesis and the expression levels of aromatase enzyme (CYP19A1) and steroidogenic acute regulatory protein. This study demonstrates the adverse effects of PP on ovarian estradiol secretion and ovulation, further evaluates the safety of PP as a preservative, and provides guidance for the use of PCPs and cosmetics by women of childbearing age.

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Section: Discussionsupporting

confidence: 92%

Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro

Jiao

Zhai

et al. 2021

J of Applied Toxicology

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“…As the vast majority of chemicals in current commercial use have not been tested at all for endocrine effects, further studies on the simultaneous detection of various endocrine disruptors should be conducted due to their possible cumulative, synergic and additive action in the human body (Pollock, Mantella, Reali, & deCatanzaro, ; Pollock, Weaver, Ghasemi, & deCatanzaro, ). Urine is the most commonly examined matrix, although serum and hair seem to reveal associations that cannot be obtained from urine analysis.…”

Section: Resultsmentioning

confidence: 99%

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Karzi

Tzatzarakis

Vakonaki

et al. 2018

J of Applied Toxicology

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Bisphenol A (BPA), triclosan (TCS) and perfluorooctanoic acid (PFOA) are endocrine disruptors linked with negative health effects such as developmental, reproductive and cardiovascular toxicity. The aim of this study was to determine simultaneously the concentration of BPA, TCS and PFOA in hair from children and adults and examine possible associations between biomonitoring data and age, gender, dietary habits and body mass index. Methanolic extraction was applied and the compounds were determined by liquid chromatography-mass spectrometry. Low levels of exposure to PFOA were detected for children and adults at concentrations below limit of quantification. The mean concentration of BPA in children and adults was 20.6 and 16.6 pg mg , while for TCS 275.2 and 687.0 pg mg , respectively. Children were highly exposed to BPA relative to adults (P = .011) although adults had greater exposure to TCS (P = .003). Hair from girls had a greater burden of BPA (P = .06) compared to boys. Moreover, higher TCS levels were depicted for females in both examined groups (children P = .200 and adults P = .213) compared to males, but no statistical differences were observed. Significant differences were also observed between age groups (P = .0007) for TCS. No correlations were found between BPA or TCS levels and body mass index or dietary habits for both children and adults. Children have a greater exposure to BPA compared to adults, whereas exposure of adults to TCS seems to be higher than that in children and elderly people. Exposure to BPA occurs mainly via ingestion whereas exposure to TCS mainly via dermal absorption.

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“…As well synergistic activation of human PXR was observed in an in vitro model of hepatocytes (HepG2) by binary cocktails of pharmaceutical and environmental compounds ( 58 ). Another limitation to the additivity concept of cocktail effect lies in the fact that a pollutant can alter the metabolism of another pollutant present in the mixture and potentially its bioavailability ( 59 ). Moreover, some products may, by modifying the epigenome, leave an imprint on unexposed generations as recently demonstrated with TBT on RXR activation ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Environmental Pollutants and Metabolic Disorders: The Multi-Exposure Scenario of Life

Magueresse-Battistoni

Vidal

Naville

2018

Front. Endocrinol.

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Obesity and diabetes have reached epidemic proportions the past few decades and continue to progress worldwide with no clear sign of decline of the epidemic. Obesity is of high concern because it is the main risk factor for a number of non-communicable diseases such as cardiovascular diseases and type 2 diabetes. Metabolic diseases constitute a major challenge as they are associated with an overall reduced quality of life and impose a heavy economic burden on countries. These are multifactorial diseases and it is now recognized that environmental exposure to man-made chemical pollutants is part of the equation. Yet, risk assessment procedures are based on a one-by-one chemical evaluation which does not meet the specificities of the multi-exposure scenario of life, e.g., a combined and long-term exposure to even the smallest amounts of chemicals. Indeed, it is assumed that environmental exposure to chemicals will be negligible based on the low potency of each chemical and that they do not interact. Within this mini-review, strong evidences are brought that exposure to low levels of multiple chemicals especially those shown to interfere with hormonal action, the so-called endocrine disrupting compounds do trigger metabolic disturbances in conditions in which no effect was expected if considering the concentration of each individual chemical in the mixture. This is known as the cocktail effect. It means that risk assessment procedures are not protective enough and thus that it should be revisited for the sake of Public Health.

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A mixture of five endocrine-disrupting chemicals modulates concentrations of bisphenol A and estradiol in mice

Cited by 34 publications

References 76 publications

Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro

Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Environmental Pollutants and Metabolic Disorders: The Multi-Exposure Scenario of Life

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