At present, "COVID-19" has spread in 184 countries (regions) in the world, and more than 500 million patients have been diagnosed and caused 66.3 million deaths. The worldwide epidemic is still ongoing, and the epidemic in China is still increasing, therefore, the regular prevention and control of the epidemic is An important part of ensuring people live, live, live, especially in crowded places, there is an urgent need for artificial intelligence, biometrics and other technologies. This paper proposes the face recognition method of sparse enhancement and collaborative information fusion. The paper first explains and generalises the relevant terms, and finally, the practicality of the algorithm is demonstrated through experimental analysis. The recognition rate of the algorithm described in this paper is generally higher than 95% on different facial masking ratios, and the results show that the face recognition method of sparse enhancement and collaborative information fusion based on epidemic prevention and control is a very worthy research The results show that face recognition based on sparse enhancement and collaborative information fusion for epidemic prevention and control is a very worthwhile research technique that can help solve the critical problems of epidemic prevention and control today.