2023
DOI: 10.1002/psp4.13065
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A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology

Javier Sánchez,
Christina Claus,
Rosmarie Albrecht
et al.

Abstract: FAP‐4‐1BBL is a bispecific antibody exerting 4‐1BB‐associated T‐cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer‐associated fibroblasts. The trimeric complex formed when FAP‐4‐1BBL is simultaneously bound to FAP and 4‐1BB represents a promising mechanism to achieve tumor‐specific 4‐1BB stimulation. We integrated in vitro data with mathematical modeling to characterize the pharmacology of FAP‐4‐1BBL as a function of trimeric … Show more

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