A Model-Based Methodology for Spray-Drying Process Development

Dobry, Dan E.; Settell, Dana M.; Baumann, John M.; Ray, Rod; Graham, Lisa; Beyerinck, Ron

doi:10.1007/s12247-009-9064-4

Cited by 192 publications

(106 citation statements)

References 16 publications

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“…Properties of the microparticles obtained with the spray drying technique do not depend only on the drying parameters such as: inlet temperature, aspirator flow, feed flow and spray flow but also on the properties of the mixture subjected to drying. The higher the concentration of the components, the higher is the density and the lower the yield (26)(27)(28). When using methacrylate copolymers to obtain microparticles by the spray drying method, a low yield of the process is often observed.…”

Section: Characterization Of Microparticles Obtained With Cet and Eudmentioning

confidence: 99%

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

et al. 2017

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Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.Keywords: taste masking, electronic tongue, cetirizine dihydrochloride, microparticles, methacrylate copolymer, spray drying Unacceptable taste is an important problem encountered in the designing of new dosage forms. Taste masking of drug substances has been continuously changing with emerging techniques and new excipients (1-7). Taste masking can be carried out by various methods, depending on the therapeutic agent and dosage form. One of the simplest taste masking methods is addition of flavors, sweeteners and effervescent agents, but it is not always effective. In recent years, methods creating a physical barrier between active ingredients and taste buds have been developed for taste masking. One of them is spray drying, a relatively simple and convenient technology for the preparation of microparticles (8)(9)(10)(11)

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Section: Characterization Of Microparticles Obtained With Cet and Eudmentioning

confidence: 99%

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

et al. 2017

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“…Using the DPM, reactions of the particles and how they affect the continuous phase can be examined using one of the heat and mass transfer laws in Fluent R (Dobry et al, 2009). The particles in this case may be composed of either pure liquid cyclohexane, pure polymer, or a combination of both.…”

Section: Discrete-phase Modelmentioning

confidence: 99%

“…Later, Woo et al (2008) discussed different spray drying methods using an Eulerian-Lagrangian modelling approach. Dobry et al (2009) emphasized the importance of mass and heat transfer in studying the drying of active soluble ingredients, and Mezhericher, Levy, and Borde (2009) used a CFD model to show droplet drying using an Eulerian-Lagrangian method. Other studies include those of Gjesing, Hattel, and Fritsching (2009), Ruiz-López, Ruiz-Espinosa, Luna-Guevara, and García-Alvarado (2011), and Sazhin (2006).…”

Section: Introductionmentioning

confidence: 99%

CFD simulations of polymer devolatilization in steam contactors

Gabor

Shindle

Chandy

2017

Engineering Applications of Computational Fluid Mechanics

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Removal of volatiles and other unwanted products in a polymer mix is a critical step in polymer manufacturing. This process serves many purposes, such as improvement in the physical and chemical properties of the polymer, elimination of odours, recovery of monomers and solvents, and fulfilment of environmental regulations. In this study, the mixture of polymer and solvent, or cement, is mixed with superheated steam which causes the unwanted solvent to evaporate. As the cement droplets lose solvent and dry out, they are ejected as cement 'crumb' from the mixing device. This process is modelled using computational fluid dynamics (CFD) to gain insight into the complex phenomena. The model simulates the heat transfer and phase changes associated with cement and steam, via 3D axisymmetric calculations. Using an Eulerian-Lagrangian approach, the superheated steam is modelled as the continuous phase and tracked in an Eulerian frame, while the cement droplets are treated using a Lagrangian tracking method, thus as a whole allowing us to track the particle sizes, temperatures, and solvent content. Furthermore, a parametric study is carried out to analyse the effect of initial polymer temperature on final polymer product. The simulation is carried out with three different initial polymer temperatures and the resulting solvent concentration, and the size of the cement particles between the three cases are compared. By increasing the cement operating temperature, the solvent concentration in the cement crumb is significantly lower, and the final cement crumb sizes shows a slight decrease, which indicates better production performance. Indeed, full 3D CFD calculations, presented to verify the axisymmetric assumption, show differences in the particle statistics, which could have implications for design considerations. Such studies can provide further insights into control parameters that can potentially enhance the efficiency of such a manufacturing process. ARTICLE HISTORY

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“…To avoid product oxidation, inert atmosphere can be obtained by using N 2 as the drying gas 60 . Also process yield can vary significantly with different drying mediums for spray drying.…”

Section: Inlet and Outlet Temperaturesmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:As time passes more and more poorly water soluble drug are being discovered. Formulating these drugs in to amorphous solid dispersion is an effective strategy to deliver poorly water soluble drugs. Spray drying is one of common and a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs). However, the spray drying is complex phenomenon and the spray drying process parameters yield the ASD with specific characteristics. Various diverse factors interact in an inter-dependent manner to determine the final product properties. This review discusses the basic background of spray drying, and various aspects of spray drying such as instrumentation, thermodynamics, drying kinetics, particle formation process and scale-up challenges are included. Recent advances in the spray-based drying techniques are mentioned along with some future avenues where major research is needed.

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A Model-Based Methodology for Spray-Drying Process Development

Cited by 192 publications

References 16 publications

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

CFD simulations of polymer devolatilization in steam contactors

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