A model compound study: The ecotoxicological evaluation of five organic contaminants employing a battery of marine bioassays

Macken, Ailbhe; Giltrap, Michelle; Foley, Barry; McGovern, Evin; McHugh, Brendan; Davoren, Maria

doi:10.1016/j.envpol.2007.09.005

Cited by 39 publications

(13 citation statements)

References 38 publications

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“…battagliai was 7.2 (95 % CI = 5.8 -9.1) mg/L, which corresponds to previously published 324 values for this species and chemical (Macken et al, 2008). No deleterious effects of PVP 325 were observed, therefore, toxicity due to the PVP capping agent in these experiments can be 326 ruled out.…”

Section: Tisbe Battagliai 322supporting

confidence: 62%

Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne

Macken

Byrne²,

Thomas

2012

Ecotoxicology and Environmental Safety

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Section: Tisbe Battagliai 322supporting

confidence: 62%

Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne

Macken

Byrne²,

Thomas

2012

Ecotoxicology and Environmental Safety

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“…After the 96-h exposure period, increased cytotoxicity was observed for the RTG-2 cells for each of the individual organotin compounds for both of the endpoints studied as evidenced by the lower EC50 values (Table 2). A parallel study conducted in our lab with Vibrio fischeri and Tisbe battagliai demonstrated a similar increase in toxicity over time with TBT-Cl [33]. Organotin chloride salts are known to degrade in aqueous solution unless stored under acidic conditions at 48C (M. Giltrap, unpublished data), and therefore it is possible that combination effects of OT compounds could have elicited a greater toxic response to the cells over the time period of 96 h. The EC50 values as well as their NOEC and LOEC values obtained for the organotins were all within one order of magnitude (see Table 2).…”

Section: Discussionmentioning

confidence: 54%

In vitro screening of organotin compounds and sediment extracts for cytotoxicity to fish cells

Giltrap

Macken

McHugh

et al. 2010

Enviro Toxic and Chemistry

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The present study reports an in vitro screening method for contaminants in sediment samples utilizing an RTG-2 cell line. This technique integrates cytotoxicity testing with analytical chemistry with the aim of achieving a toxicity evaluation of the sediment sample. The toxic effect of individual organotin (OT) compounds and their presence in the sediment sample is the focus of the present study; however, other contaminants are also discussed. The following OT compounds: tributyltin (TBT), dibutyltin (DBT), monobutyltin (MBT), triphenyltin (TPT), diphenyltin (DPT), and a sediment solvent extract are exposed to the RTG-2 fish cell line. Both the alamar blue (AB) and neutral red (NR) assays are used to assess cytotoxicity after 24-h and 96-h exposure. Methodology for preparation of a sediment solvent extract suitable for biological testing and analytical determination is also described. With the RTG-2 cells, the AB and NR assays had comparable sensitivity for each individual OT compound exposure after 24 h, with TPT being the most toxic compound tested. The individual OT compound concentrations required to induce a 50% toxic effect on the cells (369 ng ml⁻¹ TBT, 1,905 ng ml⁻¹ DBT) did not equate to the concentrations of these contaminants present in the sediment extract that induced a 50% effect on the cells (294 ng ml⁻¹ TBT, 109 ng ml⁻¹ DBT). The solvent extract therefore exhibited a greater toxicity, and this suggests that the toxic effects observed were not due to OT compounds alone. The presence of other contaminants in the solvent extract is confirmed with chemical analysis, warranting further toxicity testing of contaminant mixtures and exposure to the cell line to further elucidate a complete toxicity evaluation.

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“…This could be related with the routes of exposure of each organism to contaminants and highlights the importance of testing different matrix (i.e. solid phase and elutriates) for a reliable assessment of potential toxicity (Macken et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Integrative sediment assessment at Atlantic Spanish harbours by means of chemical and ecotoxicological tools

Montero

Belzunce-Segarra

Menchaca

et al. 2012

Environ Monit Assess

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This study refers to the integrative assessment of sediment quality in three harbour areas at the Spanish Atlantic Coast: Vigo (Northwestern Spain), Bilbao and Pasajes (Northern Spain). At each site, two lines of evidence have been considered: chemical analyses (metal, PAH and PCB concentrations in sediments and ammonia concentration in bioassays) and toxicity tests (Microtox®, Corophium sp. marine amphipod and Paracentrotus lividus sea urchin larvae). Chemical and ecotoxicological results have been integrated by means of a tabular matrix and a multivariate factorial analysis (FA). Highly toxic samples have been characterised in Vigo and Pasajes harbours while Bilbao samples present toxicity levels ranging from non-toxic to moderately toxic. High toxicity is associated with high levels of contaminants whereas confounding factors (ammonia, organic matter and mud) have been identified to be the main cause of low to moderate toxicity. Based on the obtained results, it can be concluded that deriving potential toxicity of sediments based on comparison with Sediment Quality Guidelines (SQGs) is in agreement to toxicity results in areas presenting high levels of contaminants. However, at lower levels of toxicity (low to moderate), the mismatch between the potential toxicity (SQG approach) and the toxicity measured by bioassays is greater, as the former only accounts for chemical concentrations, without considering the interaction between contaminants and the effect of confounding factors. Contrarily, the multivariate analysis seems to be a robust tool for the integration and interpretation of different lines of evidence in areas affected by different sources of contamination.

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A model compound study: The ecotoxicological evaluation of five organic contaminants employing a battery of marine bioassays

Abstract: This paper describes the ecotoxicological evaluation of five organic contaminants frequently detected in marine sediments (tributyltin, triphenyltin, benzo[a]

Cited by 39 publications

References 38 publications

Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne

Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne

In vitro screening of organotin compounds and sediment extracts for cytotoxicity to fish cells

Integrative sediment assessment at Atlantic Spanish harbours by means of chemical and ecotoxicological tools

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