A model for aganglionosis in the chicken embryo

Meijers, J.H.C.; Tibboel, Dick; Kamp, A.W.M. van der; van^Haperen-Heuts, Ilse C.C.M.; Molenaar, Jan C.

doi:10.1016/s0022-3468(89)80505-6

Cited by 41 publications

(26 citation statements)

References 14 publications

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“…This theory has been based on studies that have failed to demonstrate a contribution from the sacral crest to the ENS when the normal rostrocaudal migration of vagal NCC was prevented. For example, when the bowel was either severed in vivo to halt the migration of vagal NCC to the hindgut (Meijers et al, 1989), or removed and cultured in vitro prior to the arrival of vagal NCC (Allan and Newgreen, 1980), an ascending contribution from the sacral NC to the hindgut was not observed. Further, recent studies using markers for neurons or neuronal precursors have demonstrated a single rostrocaudal colonisation of the gut, with no apparent contribution from the sacral crest (Young et al, 1998).…”

Section: Sacral Ncc Colonise the Gut In A Caudorostral Direction Formmentioning

confidence: 99%

“…In their original investigations, in addition to reports concerning the vagal NC, Le Douarin and Teillet (1973Teillet ( , 1974 suggested that a second, more caudal region of the neuraxis, the sacral NC, may also contribute cells to the ENS. Although a number of studies have subsequently supported this theory (Pomeranz and Gershon, 1990;Pomeranz et al, 1991;Serbedzija et al, 1991), the finding has been controversial as other groups have presented contradictory evidence suggesting that the sacral NC does not play a role in ENS formation (see Allan and Newgreen, 1980;Meijers et al, 1989). The confusion concerning the fate of sacral NCC has mainly arisen due to the previous lack of phenotypic identification of sacral NC-derived cells within the gut.…”

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confidence: 99%

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Enteric nervous system development: Analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras

2001

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Section: Sacral Ncc Colonise the Gut In A Caudorostral Direction Formmentioning

confidence: 99%

mentioning

confidence: 99%

Enteric nervous system development: Analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras

2001

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“…When segments of hindgut were removed and cultured, prior to the arrival of vagal NCC, enteric neurons were not found to develop in the cultured explants (Allan and Newgreen, 1980, Kapur et al, 1992, Nishijima et al, 1990. Similarly, in midgut transection experiments, when the bowel was severed in ovo prior to the arrival of the rostrocaudally migrating vagal NCC (Meijers et al, 1989), the hindgut remained aganglionic, suggesting there was no contribution to the hindgut from the sacral crest. More recently, Young et al, (Young et al, 1998), using detailed immunohistochemical labelling of migrating NCC, described the rostro-caudal progression of vagal-derived enteric precursors along the gut.…”

Section: Enteric Nervous System Precursor Cells Are Derived From the mentioning

confidence: 99%

Migration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract

Burns¹

2005

Int. J. Dev. Biol.

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The enteric nervous system, the intrinsic innervation of the gastrointestinal tract, consists of large numbers of phenotypically diverse neurons and glial cells, arranged in complex interconnecting plexuses situated between the smooth muscle layers of the gut wall. Recently, the enteric nervous system has attracted much attention from developmental biologists whose efforts have focused on analysing the cellular origins of enteric nervous system precursor cells, how these cells migrate to and within the gut and the identification of signalling mechanisms which cause migrating cells to differentiate into the appropriate phenotypes in the appropriate locations. This review summarises the state of knowledge concerning the early stages of enteric nervous system development and concentrates on: (i) the embryological origins of the neural crest cells which colonise the gastrointestinal tract, (ii) their spatiotemporal migration within the gut, (iii) the possible pre-specification of neural crest cells as enteric nervous system precursors and (iv) factors influencing their directional migration within the gut.

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“…This model also appears in studies of esophageal atresia 2 , Hirschsprung's disease 3 , meconial peritonitis 4 , and meningomyelocele 5 . The first studies using chicken embryo as models for the study of gastroschisis appeared with TIBBOEL in Holland 6 and were followed by researchers in Spain 7 and Turkey 8 .…”

Section: Introductionmentioning

confidence: 96%

Chicken embryo as an experimental model for the study of gastroschisis

Gandara¹,

Araújo²,

Motta

2008

Acta Cir. Bras.

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PURPOSE: To reproduce the experimental model of gastroschisis in chicken embryos and to prove that the histopathological changes that occur in this model can be compared to those in human gastroschisis. METHODS: A total of 278 Leghorn hen (Gallus domesticus) eggs were used. The embryos were divided into three groups: the gastroschisis group, in which the umbilical cord was opened through an orifice made in the eggshell, and the intestinal loops were exposed to a mixture of amniotic liquid and allantoid; the mixture group, in which the amniotic fluid and allantoid were simply mixed without manipulating the umbilical stump and without exposing intestinal loops; and the control group which consisted of normal embryos in which no procedure was performed. The procedures were performed on the 13th day of embryo development and the study ended on the 19th day, when the intestinal loops of the embryos were removed and sent for conventional histological study and digital morphometric analysis. RESULTS: At the end of the experiment, 23 live embryos were obtained in the gastroschisis group (11.1% survival), and 18 of these presented exposed intestinal loops (8.7% success). The embryos of the gastroschisis group weighed less than those of the other two groups. The gastroschisis group also developed intestinal changes consisting of the thickening of the intestinal wall, inflammatory infiltration of the serosa and mucosa, ischemic changes in the intestinal wall and formation of a fibrin layer over the loops. These findings are characteristic of human gastroschisis and were not observed in the two other groups studied. CONCLUSION: The experimental model in chicken embryos proved able to reproduce the intestinal changes of human gastroschisis.

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A model for aganglionosis in the chicken embryo

Cited by 41 publications

References 14 publications

Enteric nervous system development: Analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras

Enteric nervous system development: Analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras

Migration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract

Chicken embryo as an experimental model for the study of gastroschisis

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