A Model for Chronic Mucosal Inflammation in IBD and Periodontitis

Oz, Helieh S.; Chen, Theresa; Ebersole, Jeffrey L.

doi:10.1007/s10620-009-1031-x

Cited by 29 publications

(29 citation statements)

References 44 publications

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“…These approaches have also enabled the use of genetically manipulated strains to focus on individual components of the host response and to thereby describe their role in the disease process [48, 49]. More recently, different investigators have used gingival tissue inoculated with chemicals [28, 50], microorganisms [51], or their products [52, 53] to elicit periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

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Animal Models for Periodontal Disease

Puleo

2011

BioMed Research International

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244

254

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Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontitis commonly has been induced by placing a bacterial plaque retentive ligature in the gingival sulcus around the molar teeth. In addition, alveolar bone loss has been induced by inoculation or injection of human oral bacteria (e.g., Porphyromonas gingivalis) in different animal models. While animal models have provided a wide range of important data, it is sometimes difficult to determine whether the findings are applicable to humans. In addition, variability in host responses to bacterial infection among individuals contributes significantly to the expression of periodontal diseases. A practical and highly reproducible model that truly mimics the natural pathogenesis of human periodontal disease has yet to be developed.

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Section: Introductionmentioning

confidence: 99%

“…An alternative method for inducing inflammation of oral tissues is by using trinitrobenzene sulfonic acid (TNBS) or dextran sulphate sodium (DSS) [28, 50]. These chemicals are often utilized to induce acute (1 cycle) and chronic inflammation (3–5 cycles) in the gut to evaluate progression of inflammatory bowel disease (IBD) [76–79].…”

Section: Introductionmentioning

confidence: 99%

Animal Models for Periodontal Disease

Puleo

2011

BioMed Research International

Self Cite

244

254

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“…For example, oral infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a 4-week old rodent model revealed more severe alveolar bone loss and inflammatory response when both bacteria were combined (Li & , H. Yang, Y. Ding, R. Aprecio, W. Zhang, Q. Wang, Y. Li, 2013). To model inflammatory bowel disease and periodontal disease progression in patients, 11-12 week old BALB/c mice were treated with oral delivery of DSS, which induced IBD including diarrhea, anemia, dilation of the stomach wall, dysregulated hepatic concentration, and severe alveolar bone loss (Oz et al, 2010). The ligature model allows biofilm accumulation, disrupts the gingival epithelium, and enhances bone loss.…”

Section: Use Of Animal Modelsmentioning

confidence: 99%

Oral health in geroscience: animal models and the aging oral cavity

Darveau

Kaeberlein

2017

GeroScience

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Age is the single greatest risk factor for many diseases, including oral diseases. Despite this, a majority of preclinical oral health research has not adequately considered the importance of aging in research aimed at the mechanistic understanding of oral disease. Here, we have attempted to provide insights from animal studies in the geroscience field and apply them in the context of oral health research. In particular, we discuss the relationship between the biology of aging and mechanisms of oral disease. We also present a framework for defining and utilizing age-appropriate rodents and present experimental design considerations, such as the number of age-points used and the importance of genetic background. While focused primarily on rodent models, alternative animal models that may be particularly useful for studies of oral health during aging, such as companion dogs and marmoset monkeys, are also discussed. We hope that such information will aid in the design of future preclinical studies of geriatric dental health, thus allowing more reliability for translation of such studies to age-associated oral disease in people.

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“…Periodontal disease and IBDs are characterized by chronic inflammation and share a number of similar pathophysiological features [60]. Similar to IBDs, periodontal disease is a chronic relapsing inflammatory disease of periodontal tissues.…”

Section: Oral Manifestations Of Ibdsmentioning

confidence: 99%

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Vasovic¹,

Gajovic²,

Brajković³

et al. 2016

cejoi

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Inflammatory bowel diseases (IBDs) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as Crohn’s disease and ulcerative colitis. The etiology of IBDs is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. Clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. Changes in the oral cavity often precede intestinal symptoms. Inflammatory bowel disease leads to a significant deterioration of oral health, which indicates that cooperation between the dentist and the gastroenterologist is necessary when considering patients’ welfare. Patients with IBD have an altered immune response, but microorganisms of the oral cavity may also be responsible for its modification.This review paper discusses the correlation between the immune system and inflammatory bowel disease manifestations in the oral cavity.

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A Model for Chronic Mucosal Inflammation in IBD and Periodontitis

Abstract: This model of mucosal stimulation eliciting chronic inflammatory responses in the gut and oral cavity mimics aspects of IBD and periodontal disease progression in patients.

Cited by 29 publications

References 44 publications

Animal Models for Periodontal Disease

Animal Models for Periodontal Disease

Oral health in geroscience: animal models and the aging oral cavity

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

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