A model for the control of malaria using genetically modified vectors

Diaz, Hernando; Ramírez, Augusto; Olarte, Andres; Clavijo, Carlos

doi:10.1016/j.jtbi.2011.01.053

Cited by 30 publications

(18 citation statements)

References 19 publications

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“…There are mathematical models in the literature formulated to study the interactive dynamics of mosquito populations or the control of mosquitoes [4,5,6,9,12,13,15,16,17,19,20,21]. Models for vectorborne diseases, incorporating transgenic or sterile mosquitoes, are also formulated to study the disease transmission dynamics in [1,10,11,18,24].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Mosquitoes Populations with Different Strategies for Releasing Sterile Mosquitoes

Cai¹,

Ai²,

Li³

2014

SIAM J. Appl. Math.

107

139

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To prevent the transmissions of malaria, dengue fever, or other mosquito-borne diseases, one of the effective weapons is the sterile insect technique in which sterile mosquitoes are released to reduce or eradicate the wild mosquito population. To study the impact of the sterile insect technique on disease transmission, we formulate continuous-time mathematical models for the interactive dynamics of the wild and sterile mosquitoes, incorporating different strategies in releasing sterile mosquitoes. We investigate the model dynamics and compare the impact of the different release strategies. Numerical examples are also given to demonstrate rich dynamical features of the models.

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Section: Introductionmentioning

confidence: 99%

Dynamics of Mosquitoes Populations with Different Strategies for Releasing Sterile Mosquitoes

Cai¹,

Ai²,

Li³

2014

SIAM J. Appl. Math.

107

139

View full text Add to dashboard Cite

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“…Mathematical models have been formulated to study the interactive dynamics of wild and sterile mosquito populations or the control of mosquitoes [6,7,9,11,13,14,15,16,17,18,19,23,24,34,35,36,38,39], among which the models in [6,23] involve three different strategies in the releases of sterile mosquitoes with constant release rate, the rate proportional to the wild mosquitoes, and the rate proportional to wild mosquitoes with saturation. It is assumed in [6] that the mosquito population follows the logistic growth in the absence of interactions, and considered homogeneous mosquito populations without distinguishing the four distinct stage of development during a lifetime: egg, pupa, larva, and adult.…”

Section: Introduction Sterile Insect Technique (Sit) Is a Promising mentioning

confidence: 99%

A delayed differential equation model for mosquito population suppression with sterile mosquitoes

Yang¹,

Lin²,

Yu³

et al. 2020

Discrete &Amp; Continuous Dynamical Systems - B

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The technique of sterile mosquitoes plays an important role in the control of mosquito-borne diseases such as malaria, dengue, yellow fever, west Nile, and Zika. To explore the interactive dynamics between the wild and sterile mosquitoes, we formulate a delayed mosquito population suppression model with constant releases of sterile mosquitoes. Through the analysis of global dynamics of solutions of the model, we determine a threshold value of the release rate such that if the release threshold is exceeded, then the wild mosquito population will be eventually suppressed, whereas when the release rate is less than the threshold, the wild and sterile mosquitoes coexist and the model exhibits a complicated feature. We also obtain theoretical results including a sufficient and necessary condition for the global asymptotic stability of the zero solution. We provide numerical examples to demonstrate our results and give brief discussions about our findings.

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“…Therefore, in addition to the Vida3 cassette, the strain expresses two fluorescence markers (ECFP and DsRed2), both under control of the eye-specific 3×P3 promoter. The fitness costs associated with inbreeding have been well documented [12], [13] and a study modelling the population dynamic effect following the introduction of a genetically modified mosquito into a wild-type population concluded that the relative fitness of the resulting hemizygotes is crucial for a successful release [29]. Hemizygotes were therefore chosen for this study and were generated by outcrossing EVida3 homozygotes to the parental KIL laboratory strain from which they were derived in order to equalize genetic backgrounds [25].…”

Section: Introductionmentioning

confidence: 99%

Transgenic Anopheles gambiae Expressing an Antimalarial Peptide Suffer No Significant Fitness Cost

2014

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Mosquito-borne diseases present some of the greatest health challenges faced by the world today. In many cases, existing control measures are compromised by insecticide resistance, pathogen tolerance to drugs and the lack of effective vaccines. In light of these difficulties, new genetic tools for disease control programmes, based on the deployment of genetically modified mosquitoes, are seen as having great promise. Transgenic strains may be used to control disease transmission either by suppressing vector populations or by replacing susceptible with refractory genotypes. In practice, the fitness of the transgenic strain relative to natural mosquitoes will be a critical determinant of success. We previously described a transgenic strain of Anopheles gambiae expressing the Vida3 peptide into the female midgut following a blood-meal, which exhibited significant protection against malaria parasites. Here, we investigated the fitness of this strain relative to non-transgenic controls through comparisons of various life history traits. Experiments were designed, as far as possible, to equalize genetic backgrounds and heterogeneity such that fitness comparisons focussed on the presence and expression of the transgene cassette. We also employed reciprocal crosses to identify any fitness disturbance associated with inheritance of the transgene from either the male or female parent. We found no evidence that the presence or expression of the effector transgene or associated fluorescence markers caused any significant fitness cost in relation to larval mortality, pupal sex ratio, fecundity, hatch rate or longevity of blood-fed females. In fact, fecundity was increased in transgenic strains. We did, however, observe some fitness disturbances associated with the route of inheritance of the transgene. Maternal inheritance delayed male pupation whilst paternal inheritance increased adult longevity for both males and unfed females. Overall, in comparison to controls, there was no evidence of significant fitness costs associated with the presence or expression of transgenes in this strain.

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A model for the control of malaria using genetically modified vectors

Cited by 30 publications

References 19 publications

Dynamics of Mosquitoes Populations with Different Strategies for Releasing Sterile Mosquitoes

Dynamics of Mosquitoes Populations with Different Strategies for Releasing Sterile Mosquitoes

A delayed differential equation model for mosquito population suppression with sterile mosquitoes

Transgenic Anopheles gambiae Expressing an Antimalarial Peptide Suffer No Significant Fitness Cost

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