A Model for Vestibular Function in Altered Gravitational States

Baumgarten, R. J. von; Thümler, Reiner

doi:10.1016/b978-0-08-023416-8.50025-8

Cited by 89 publications

(30 citation statements)

References 2 publications

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“…In the 2 patients with a uVD, the utricular gain was halved. Those findings corroborate the linear and additive character of the utricular response, as has already been proposed by other authors [von Baumgarten and Thümler, 1979;Wetzig et al, 1990;Diamond and Markham, 1998;Clarke et al, 1999;Kondrachuk, 2003;Wuyts et al, 2003]. The bias, the offset value of the utricular response, corresponds to the intercept of the linear regression model by Wuyts et al [2003] and is correlated with the asymmetry.…”

Section: Discussionsupporting

confidence: 77%

“…In the past two decades, technology advancement has enabled the detailed exploration of the otolith system with the elaboration of the unilateral centrifugation test [Clarke et al, 1996;Clarke and Engelhorn, 1998;Wuyts et al, 2003] as initially conceived by Yegorov and Samarin [1970], von Baumgarten and Thümler [1979] and Wetzig et al [1990]. Throughout the past years, we have built up extensive experience with the unilateral centrifugation test ] both in healthy subjects and patients with specific (vestibular) lesions.…”

mentioning

confidence: 99%

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A New Model for Utricular Function Testing Using a Sinusoidal Translation Profile during Unilateral Centrifugation

Buytaert

Nooij

Neyt³

et al. 2010

Audiol Neurotol

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The utricle plays an important role in orientation with respect to gravity. The unilateral centrifugation test allows a side-by-side investigation of both utricles. During this test, the subject is rotated about an earth-vertical axis at high rotation speeds (e.g. 400°/s) and translated along an interaural axis to consecutively align the axis of rotation with the left and the right utricle. A simple sinusoidal translation profile (0.013 Hz; amplitude = 4 cm) was chosen. The combined rotation and translation induces ocular counter rolling (OCR), which is measured using 3-D video-oculography. This OCR is the sum of the reflexes generated by both the semicircular canals and the utricles. In this paper, we present a new physiological model that decomposes this total OCR into a canal and a utricular contribution, modelled by a second-order transfer function and a combination of 2 sine functions, respectively. This model yields parameters such as canal gain, cupular and adaptation time constants and a velocity storage component for the canals. Utricular gain, bias, phase and the asymmetry between the left and the right utricle are characteristic parameters generated by the model for the utricles. The model is presented along with the results of 10 healthy subjects and 2 patients with a unilateral vestibular loss due to acoustic neuroma surgery to illustrate the effectiveness of the model.

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Section: Discussionsupporting

confidence: 77%

mentioning

confidence: 99%

A New Model for Utricular Function Testing Using a Sinusoidal Translation Profile during Unilateral Centrifugation

Buytaert

Nooij

Neyt³

et al. 2010

Audiol Neurotol

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“…Von Baumgarten and his colleagues have suggested that asymmetries in otolith function between the two labyrinths, which result from different masses of the otoconia, cause MS ( 31 ). In support of the otolith asymmetry hypothesis, subjects with large asymmetries between their ocular counter-rolling responses for leftward and rightward body tilts were found to be signifi cantly more susceptible to MS when passively exposed to variations in gravito-inertial force load ( 9 , 18 , 23 ).…”

mentioning

confidence: 88%

Ocular Vestibular Evoked Myogenic Potentials and Motion Sickness Susceptibility

Xie¹,

Chen²,

Jia³

et al. 2012

aviat space environ med

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“…It has been hypothesised that asymmetries in the otolith function, resulting from differences in the otoconial masses between the two labyrinths, cause motion sickness (von Baumgarten and Thumber 1979). This hypothesis was further boosted by the results of studies which demonstrated the existence of higher susceptibility to motion sickness on passive exposure to variations in gravito-inertial force load in those who exhibited larger asymmetry between the rightward and leftward body tilts on ocular counter-rolling test (Lackner et al 1987;Diamond and Markham 1992a;Parker 1998).…”

Section: Introductionmentioning

confidence: 96%

Assessment of otolith function using cervical and ocular vestibular evoked myogenic potentials in individuals with motion sickness

2014

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The involvement of otolith organs in motion sickness has long been debated; however, equivocal findings exist in literature. The present study thus aimed at evaluating the otolith functioning in individuals with motion sickness. Cervical and ocular vestibular evoked myogenic potentials were recorded from 30 individuals with motion sickness, 30 professional drivers and 30 healthy individuals. The results revealed no significant difference in latencies and amplitudes between the groups (p>0.05). Nonetheless, thresholds were significantly elevated and inter-aural asymmetry ratio significantly higher in motion sickness susceptible group (p < 0.001) for both the potentials. All the individuals in the motion sickness group had high asymmetry ratio at least on one of the two potentials. Thus, reduced response and/or asymmetric otolithic function seem the likely reasons behind motion sickness susceptibility.

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A Model for Vestibular Function in Altered Gravitational States

Cited by 89 publications

References 2 publications

A New Model for Utricular Function Testing Using a Sinusoidal Translation Profile during Unilateral Centrifugation

A New Model for Utricular Function Testing Using a Sinusoidal Translation Profile during Unilateral Centrifugation

Ocular Vestibular Evoked Myogenic Potentials and Motion Sickness Susceptibility

Assessment of otolith function using cervical and ocular vestibular evoked myogenic potentials in individuals with motion sickness

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