A model framework for computer simulation of overall renal function

Cameron, W.

doi:10.1016/0022-5193(77)90302-2

Cited by 21 publications

(21 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Slope of autonomic heart multiplier 0.3 -b 4 Slope of autonomic systemic multiplier 0.5 -b 5 Slope of UO-MAP curve 0.91 mL./minute/mmHg b 6 Slope …”

Section: Appendix Amentioning

confidence: 99%

State variable approach to the analysis of neural control of long term blood pressure dynamics

Shahin

Maka

2011

Asian Journal of Control

View full text Add to dashboard Cite

The causal role of abnormal arterial blood pressure regulation in the pathogenesis of cardiovascular diseases is well established. The aim of this work is to investigate whether, and to what extent, the complex interactions between autonomic nervous control and cardiovascular systems contribute to the dynamics of long term blood pressure regulation. This paper demonstrates how a simple state variable model can be used to provide guidance concerning the mechanisms involved, which is useful for the study of parametric changes in hypertensive situations. Thus, a third-order linear state space representation has been developed for the analysis of system properties, such as Eigenvalues, stability, and dynamic behaviour of the cardiovascular-renal system. The closed-loop poles of the system under normal and pathological conditions have been evaluated through the root locus technique, which presents applications for sensitivity study and anticipated responses. The simulation results show that the magnitudes and shapes of the variables for the developed model are in good agreement with those of the actual nonlinear model under specific pathophysiological conditions. Therefore, we suggest that the system theory techniques facilitate new insights into the mechanisms involved in the functional status of cardiovascular regulation, leading to useful predictions and clinical applications.

show abstract

“…Slope of autonomic heart multiplier 0.3 -b 4 Slope of autonomic systemic multiplier 0.5 -b 5 Slope of UO-MAP curve 0.91 mL./minute/mmHg b 6 Slope …”

Section: Appendix Amentioning

confidence: 99%

State variable approach to the analysis of neural control of long term blood pressure dynamics

Shahin

Maka

2011

Asian Journal of Control

View full text Add to dashboard Cite

show abstract

“…3 (a) shows the time response of MAP, when the model is subjected to AL loading in which AL was set to double the normal value for continuous ingestion. hormone intake is a dominant factor in the blood pressure regulation [4], [6]. The model has been studied by predicting the response under aldosterone loading conditions.…”

Section: Amodel Responsementioning

confidence: 99%

“…The twelfth order model form Cameron[4] is a moderately complex representation, but has not included autonomous nervous activity (ANA). Mathematicalmodel due to Uttamsingh et al [5] provides a detailed representation of the kidney in connection with hormonal control also lacks the ANA component.…”

mentioning

confidence: 99%

Multiple tuned model approach for the analysis of nonlinear dynamics of the long term blood pressure regulation

Shahin

Maka

2010

2010 International Conference on Systems in Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…3,6,27 However, these will not be considered in this paper, since they do not introduce any novelty to Guyton's model as far as the renal sympathetic nerve activity is concerned.…”

Section: Some Mathematical Models Of the Cardiovascular/renal Systemmentioning

confidence: 99%

Long-Term Mathematical Model Involving Renal Sympathetic Nerve Activity, Arterial Pressure, and Sodium Excretion

et al. 2005

View full text Add to dashboard Cite

This paper presents a physiological long-term model of the cardiovascular system. It integrates the previous models developed by Guyton, Uttamsingh and Coleman. Additionally it introduces mechanisms of direct effects of the renal sympathetic nerve activity (rsna) on tubular sodium reabsorption and renin secretion in accordance with experimental data from literature. The resulting mathematical model constitutes the first long-term model of the cardiovascular system accounting for the effects of rsna on kidney functions in such detail. The objective of developing such a model is to observe the consequences of long-term rsna increase and impairment of rsna inhibition under volume loading. This model provides an understanding of the rsna-related mechanisms, which cause mean arterial pressure increase in hypertension and total sodium amount increase (sodium retention) in congestive heart failure, nephrotic syndrome and cirrhosis.

show abstract

A model framework for computer simulation of overall renal function

Cited by 21 publications

References 22 publications

State variable approach to the analysis of neural control of long term blood pressure dynamics

State variable approach to the analysis of neural control of long term blood pressure dynamics

Multiple tuned model approach for the analysis of nonlinear dynamics of the long term blood pressure regulation

Long-Term Mathematical Model Involving Renal Sympathetic Nerve Activity, Arterial Pressure, and Sodium Excretion

Contact Info

Product

Resources

About