A Model of Irritant‐induced Bronchoconstriction in the Spontaneously Breathing Guinea‐pig

Allott, Christopher P.; Evans, David P.; Marshall, Philip

doi:10.1111/j.1476-5381.1980.tb10921.x

Cited by 17 publications

(13 citation statements)

References 13 publications

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“…In earlier studies in guinea-pigs it was found that a large dose of isoprenaline inhibits cough [7,27]. The pre sent data extend the previous results and demonstrate a concentration-related inhibition of both cough and bronchoconstriction by a (T-agonist and two xanthine deriva tives.…”

Section: Discussionsupporting

confidence: 79%

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Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

Forsberg¹,

Karlsson²,

Zackrisson³

et al. 1992

Respiration

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In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by β₂-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree, in many respects, with that observed in asthmatic subjects.

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Section: Discussionsupporting

confidence: 79%

“…This study confirmed that the bron choconstriction induced by citric acid in guinea-pigs in volves a muscarinic mechanism [6,7]. Citric acid-induced bronchoconstriction is also attenuated by atropine in man [8].…”

Section: Discussionsupporting

confidence: 74%

Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

Forsberg¹,

Karlsson²,

Zackrisson³

et al. 1992

Respiration

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“…Therefore, airway contractility affects the frequency of cough induction. It is known that citric acid induced cough is produced by effects on bronchoconstriction involving with the muscarinic mechanism [2,7]. Vagal blocking by atropine aerosols significantly decreased the number of coughs in both BHS and BHR.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a larger contribution of airway C-fibers on the airway contraction was observed in BHS compared with BHR in a preliminary experiment. It is known that citric acid-induced cough is produced by the effect of citric acid on capsaicin-sensitive sensory neurons [6,7], while the bronchoconstriction induced by citric acid in guinea pigs involves a muscarinic mechanism [2,6]. It is, therefore, interesting to investigate the relationship between cough occurrence and airway sensitivity in these model animals with different muscarinic functions and the role of C-fibers in the airway.…”

Section: Discussionmentioning

confidence: 99%

The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

et al. 2001

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Cough elicitation and major physiological factors influencing cough occurrence were investigated in congenitally bronchial-hypersensitive (BHS) and -hyposensitive (BHR) guinea pigs exposed to citric acid (0.3 M) aerosol for 10 min. The number of cough in BHS was significantly larger than in BHR, while the latency to cough in BHS was significantly shorter than in BHR. Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR. The salbutamol, atropine and capsaicin pretreatments prolonged the cough latency in BHS, but only salbutamol prolonged the latency in BHR. After salbutamol pretreatment all BHR guinea pigs exhibited cough, while 66.7% of BHS guinea pigs exhibited it. Vagal blocking by atropine suppressed coughing in both BHS and BHR. Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment. The present study demonstrated that the cough responsiveness to citric acid aerosol was significantly higher in BHS than in BHR. It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.

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“…Inhalation of an aqueous solution of citric acid is known to cause airway chemoreceptor irritation in man and in guinea-pig, and this response appears to involve sensory mechanisms linked to the cough re¯ex (Kase 1968;Turner 1968). It has been demonstrated that citric acid-induced cough by stimulating sensitive sensory nerves and bronchoconstriction induced by citric acid in guinea-pigs involves a muscarinic mechanism (Allott et al 1980;Forsberg & Karlsson 1986;Forsberg et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Effects of Some Malian Medicinal Plants on the Respiratory Tract of Guinea-pigs

Occhiuto

Sanogo

Germanò

et al. 1999

Journal of Pharmacy and Pharmacology

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Crossopteryx febrifuga, Pteleopsis suberosa and Entada africana are used in Mali traditional medicine for fever and various respiratory diseases. We have investigated the effects of these three drugs in the form of a decoction on the respiratory tract using different experimental models. On citric acid-induced cough in guinea-pigs, the three drugs significantly decreased the number of coughs at the doses of 250 (P < 0.01), 500 (P < 0.05; P < 0.01) and 1000 (P < 0.01) mg kg(-1). The percent inhibition was respectively 62.86, 69.03 and 77.44% for C. febrifuga, 57.80, 53.90 and 61.40% for E. africana, and 37.13, 42.44 and 73.72% for P. suberosa. Codeine phosphate (10 mg kg(-1)) used as reference drug showed an inhibition of 76.32%. E. africana (1000 mg kg(-1)) reduced (65% inhibition) significantly (P < 0.05) bronchoconstriction induced by histamine (99.25% and 34.00% for control and extract, respectively). Furthermore, E. africana (1000 mg kg(-1)) provoked a bronchodilatation response when administered under basal conditions. On antigen-induced bronchospasm, C. febrifuga protected (54% inhibition) sensitized guinea-pigs with a pulmonary ventilation pressure (PVP) of 24.87% (control value < 55.00%). P. suberosa was inactive in both experimental models. The reference drug, disodium cromoglycate (10 mg kg(-1), i.v.) protected significantly (P < 0.05) with a PVP of 12.00% (78% of inhibition). This study confirmed the traditional use of these plants in the treatment of cough and other respiratory disorders.

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A Model of Irritant‐induced Bronchoconstriction in the Spontaneously Breathing Guinea‐pig

Cited by 17 publications

References 13 publications

Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

Effects of Some Malian Medicinal Plants on the Respiratory Tract of Guinea-pigs

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