A Model of Plasma-Biofilm and Plasma-Tissue Interactions at Ambient Pressure

Chen, C.; Liu, D. X.; Liu, Z. C.; Yang, Aijun; Chen, H. L.; Shama, Gilbert; Kong, Michael G.

doi:10.1007/s11090-014-9545-1

Cited by 170 publications

(128 citation statements)

References 165 publications

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“…Apart from that, oxidation of lipids by hydroxyl radicals is described in the literature. Detailed mechanisms have been proposed, but this issue is still debatable.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Atmospheric-Pressure Guided Streamer (Plasma Bullet) Influence on Liposomes with Different Composition and Physicochemical Properties

Svarnas

Matrali

Antimisiaris

2015

Plasma Process. Polym.

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The role of lamellarity and composition of liposomal membranes in the degree of their disruption by plasma bullets is investigated. Multilamellar and unilamellar vesicle liposomes consisted of phosphatidylcholine, different amounts of cholesterol, and encapsulating calcein as a reporter molecule, are prepared. Plasma‐induced release of calcein from liposomes is used for evaluating the degree of plasma influence on the lipid bilayers. Presence of cholesterol in liposomal membranes below 50 mol%, results in increased disruption by the plasma, while liposomes with 50 mol% cholesterol are resistant. Addition of negative charged lipid in the liposomes (which results in vesicles with negative zeta‐potential) makes them more labile to the plasma and induces post‐treatment effects. Finally, it is clearly demonstrated that unilamellar liposomes are readily disordered by the plasma, as compared to multilamellar ones.

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“…Apart from that, oxidation of lipids by hydroxyl radicals is described in the literature. Detailed mechanisms have been proposed, but this issue is still debatable.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Atmospheric-Pressure Guided Streamer (Plasma Bullet) Influence on Liposomes with Different Composition and Physicochemical Properties

Svarnas

Matrali

Antimisiaris

2015

Plasma Process. Polym.

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“…Applications stemming from the interactions of plasmas and liquids include biomedicine and biological disinfection [3][4][5][6][7][8], chemical disinfection [9][10][11], and agricultural uses [12,13]. To most effectively utilize plasma-liquid systems requires a fundamental knowledge of their behavior; many researchers are now actively contributing to that knowledge through both experimental [1][2][14][15][16][17][18][19] and modelling efforts [20][21][22][23]. Though much progress has been made, there is still much that is unknown, particularly in the interfacial region where the plasma meets the liquid.…”

Section: Introductionmentioning

confidence: 99%

Fully coupled simulation of the plasma liquid interface and interfacial coefficient effects

Lindsay¹,

Graves²,

Shannon³

2016

J. Phys. D: Appl. Phys.

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There is a growing interest in the study of coupled plasma-liquid systems because of their applications to biomedicine, biological and chemical disinfection, agriculture, and other areas. Optimizing these applications requires a fundamental understanding of the coupling between phases. Though much progress has been made in this regard, there is still more to be done. One area that requires more research is the transport of electrons across the plasma-liquid interface. Some pioneering works (Rumbach et al 2015 Nat. Commun. 6, Rumbach et al 2015 J. Phys. D: Appl. Phys. 48 424001) have begun revealing the near-surface liquid characteristics of electrons. However, there has been little work to determine the near-surface gas phase electron characteristics. Without an understanding of the near-surface gas dynamics, modellers are left to make assumptions about the interfacial conditions. For instance it is commonly assumed that the surface loss or sticking coefficient of gas-phase electrons at the interface is equal to 1. In this work we explore the consequences of this assumption and introduce a couple of ways to think about the electron interfacial condition. In one set of simulations we impose a kinetic condition with varying surface loss coefficient on the gas phase interfacial electrons. In a second set of simulations we introduce a Henry's law like condition at the interface in which the gas-phase electron concentration is assumed to be in thermodynamic equilibrium with the liquid-phase electron concentration. It is shown that for a range of electron Henry coefficients spanning a range of known hydrophilic specie Henry coefficients, the gas phase electron density in the anode can vary by orders of magnitude. Varying reflection of electrons by the interface also has consequences for the electron energy profile; increasing reflection may lead to increasing thermalization of electrons depending on choices about the electron energy boundary condition. This variation in anode electron density and energy as a function of the interface characteristics could also lead to significant variation in near-surface gas chemistries when such reactions are included in the model; this could very well in turn affect the reactive species impinging on the liquid surface. We draw the conclusion that in order to make more confident model predictions about plasma-liquid systems, finer scale simulations and/or new experimental techniques must be used to elucidate the near-surface gas phase electron dynamics.

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“…electrons, He + , metastable He and exited He 2 ) and the ambient air. [11] The delivery of the APPJ reactive species into liquid and tissue have been studied through theoretical modelling [13,14].…”

Section: Introductionmentioning

confidence: 99%

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

Szili

Gaur

et al. 2015

J. Photopol. Sci. Technol.

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We demonstrated the efficacy of using a simple experimental approach, involving UV absorption spectroscopy, to monitor the transport of reactive oxygen and nitrogen species (RONS) through an agarose film (as surrogate for real tissue) into deionized (DI) water. The experiment involved placing a 4 mm thick agarose film over a quartz cuvette filled with DI water. The agarose film was exposed to a non-thermal, He atmospheric-pressure plasma jet (APPJ) and the UV absorption of the DI water was recorded in real-time. Our results indicate an accumulation of RONS within the agarose film during APPJ exposure and a subsequent time-lapsed release of RONS into the DI water. Curve fitting of the UV spectra suggested the APPJ transported and / or generated at least four RONS (NaNO 2 , HNO 3 , H 2 O 2 and O 2 ) through the 4 mm thick agarose film. Our approach of analyzing the delivery depth of RONS through synthetic tissue targets might find use in the future development of APPJ medical therapies and for improving our understanding of APPJ interactions with soft tissue.

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A Model of Plasma-Biofilm and Plasma-Tissue Interactions at Ambient Pressure

Cited by 170 publications

References 165 publications

Assessment of Atmospheric-Pressure Guided Streamer (Plasma Bullet) Influence on Liposomes with Different Composition and Physicochemical Properties

Assessment of Atmospheric-Pressure Guided Streamer (Plasma Bullet) Influence on Liposomes with Different Composition and Physicochemical Properties

Fully coupled simulation of the plasma liquid interface and interfacial coefficient effects

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

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