A model of the cobalamin-independent methionine synthase reaction

Methyl transfer from nitrogen to cobalt: model for the B12-dependent methyl transfer enzymes

“…(sealed tube at 100 "C for 24 h, 2% yield)3 and a N5dimethylated pterin derivative (70 "C for 24 h, 57% yield), as reported recently by Hilhorst, Chen and Pandit. 5 No methyl transfer from N to Co in a corrinoid has yet been reported in reasonable yield, though Hilhorst reports 'an extremely low conversion' with her pterin derivative . 4 CoI-Cbl does, however, react readily with ethyleneimine to give the Co-CH2CH2NH3+ derivative , 6 demonstrating that alkyl transfer from N to Co can occur provided there is a sufficient driving force.…”