A Modern Technology Applied in Traditional Chinese Medicine: Progress and Future of the Nanotechnology in TCM

Yan, Guoquan; Wang, Yonglin; Han, Xinxin; Zhang, Qian; Xie, Hui; Chen, Jun; Ji, De; Mao, Chunqin; Lu, Tulin

doi:10.1177/1559325819872854

Cited by 23 publications

(15 citation statements)

References 28 publications

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“…For herb medicines, which are richer in fibers and thus more difficult to crush, the preferred method is extracting techniques with aqueous solutions. 67 Here, the modernization of these preparation technologies would keep up with the competitive advantages of modern chemical drugs in terms of purity, dosage, and production capacity. Remarkably, improved preparation technologies can also enhance the physicochemical properties.…”

Section: Weaknesses Of Tcmmentioning

confidence: 99%

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

et al. 2022

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The integration of progressive technologies such as nanomedicine with the use of natural products from traditional medicine (TM) provides a unique opportunity for the longed-for harmonization between traditional and modern medicine. Although several actions have been initiated decades ago, a disparity of reasons including some misunderstandings between each other limits the possibilities of a truly complementation. Herein, we analyze some common challenges between nanomedicine and traditional Chinese medicine (TCM). These challenges, if solved in a consensual way, can give a boost to such harmonization. Nanomedicine is a recently born technology, while TCM has been used by the Chinese people for thousands of years. However, for these disciplines, the regulation and standardization of many of the protocols, especially related to the toxicity and safety, regulatory aspects, and manufacturing procedures, are under discussion. Besides, both TCM and nanomedicine still need to achieve a wider social acceptance. Herein, we first briefly discuss the strengths and weaknesses of TCM. This analysis serves to focus afterward on the aspects where TCM and nanomedicine can mutually help to bridge the existing gaps between TCM and Western modern medicine. As discussed, many of these challenges can be applied to TM in general. Finally, recent successful cases in scientific literature that merge TCM and nanomedicine are reviewed as examples of the benefits of this harmonization.

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Section: Weaknesses Of Tcmmentioning

confidence: 99%

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

et al. 2022

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“…In recent years, nanotechnology-based drug delivery systems have received considerable attention for their potential to improve drug stability and solubility and increase circulation times in vivo [30,282]. Nanoparticles made from poly(lactic-co-glycolic acid) (PLGA) are recognized as effective drug carriers because of their long circulation time, high stability and carrier capacity, and diverse delivery routes.…”

Section: Polyphenol Delivery Strategies For Is Therapymentioning

confidence: 99%

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

et al. 2022

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Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. In the past few decades, polyphenolic compounds have shown great potential in animal models of IS because of their high biocompatibility and ability to target multiple ischemic cascade signaling pathways, although low bioavailability is an issue that limits the applications of several polyphenols. Here, we review the pathophysiological changes following cerebral ischemia and summarize the research progress regarding the applications of polyphenolic compounds in the treatment of IS over the past 5 years. Furthermore, we discuss several potential strategies for improving the bioavailability of polyphenolic compounds as well as some essential issues that remain to be addressed for the translation of the related therapies to the clinic.

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“…Nanotechnology is a molecular scale system and applying in Chinese medicine for the development of nanoparticle drug-delivery vehicles. These nano-carriers are less than 100 nm in size with an ability to carry and deliver therapeutics to infection sites [2] . It is well-known that most of the active compounds from TCM are poor solubility and low bioavailability with limited applications in clinical settings.…”

Section: Dear Editormentioning

confidence: 99%

Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

Law¹,

Leung

2021

Photodiagnosis and Photodynamic Therapy

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A Modern Technology Applied in Traditional Chinese Medicine: Progress and Future of the Nanotechnology in TCM

Cited by 23 publications

References 28 publications

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

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