In this paper, a textile two-port multi-input multi-output (MIMO) half-circle antenna with corrugated borders is designed and fully analyzed for nearfield ultra-wideband biomedical diagnostic applications. The orthogonal polarization technique is introduced for mutual coupling reduction, signal quality, and imaging accuracy improvement. A low pass filter with significant out-of-band rejection is inserted between the two MIMO structural elements to improve the isolation from element to element. For simple system integration, A 50 ohms feed coplanar waveguide is suggested for each element. The entire antenna is constructed using textile materials, with the radiating element composed of conductor fabric. The substrate, on the other hand, is crafted from cotton material which possesses a relative permittivity of and a tan δ value of 0.025. The size of each antenna element has low-profile dimensions of 40 × 40 × 0.3 $${mm}^{3}$$
mm
3
. The measured results obtained demonstrate an extremely broad bandwidth extends from 2.5 GHz to 12 GHz. Omnidirectional radiation pattern is obtained, with 6 dBi maximum gain and 96% efficiency. In order to ensure flexibility, a range of bending conditions were analyzed, and the durability was assessed through wash ability testing. Safety was confirmed by measuring the specific absorption rate. Furthermore, time domain and MIMO performance assessments were performed to ensure its suitability for imaging systems.