Low-voltage trigger silicon-controlled rectifier (LVTSCR) has attracted widespread attention due to its trigger capability at a low voltage range. However, the relatively low holding voltage of traditional LVTSCR potentially increases the risk of latch-up. In this paper, a novel structure of LVTSCR with low trigger voltage and high holding voltage has been proposed for electrostatic discharge (ESD) protection. The proposed ESD protection device possesses an ESD implant and a floating n-well which enhances the current discharge capability of the Gate-grounded NMOS and weakens the current gain of the silicon-controlled rectifier current path. Based on the simulation results, the proposed device retains a low trigger voltage characteristic of LVTSCR and simultaneously increases the holding voltage to 5.53 V, providing an effective way to meet the ESD protection requirement of the 5 V CMOS process.