A modified (once a day) corticosteroid dosage regimen

Demos, Christopher H.; Krasner, Frank; Groel, John T.

doi:10.1002/cpt196456part1721

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…Many studies have shown that the degree of suppression may be diminished if the corticosteroid is given intermittently, for instance in a single dose on alternate days or less frequently (Ackerman and Nolan, 1968;Carter and James, 1972;Harter, Reddy, and Thorn, 1963;MacGregor, and others, 1969;Soyka, 1972). Unfortunately, administration less frequently than every day does not always provide satisfactory symptomatic relief, particularly in the treatment of painful conditions such as rheumatoid arthritis (Demos, Krasner, and Groel, 1964).…”

mentioning

confidence: 99%

Single daily dose corticosteroid treatment.

Myles¹,

Schiller²,

Glass³

et al. 1976

Annals of the Rheumatic Diseases

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. (1976). Annals ofthe Rheumatic Diseases, 35,[73][74][75][76]. Single daily dose corticosteroid treatment. Thirteen patients with rheumatoid or psoriatic arthritis who had not previously received corticosteroids were treated with prednisolone in a single dose each morning. Insulin-hypoglycaemia tests were performed before starting steroids in each patient, and again at the conclusion ofthe study in twelve of the thirteen (duration of steroid treatment 8-40 m). There was no difference in the mean basal or peak levels of corticosteroids, or the mean peak of growth hormone (GH) in the tests done before or during treatment, although one patient lost GH responsiveness. There was thus no evidence of hypothalamo-pituitary-adrenal (HPA) suppression in any of the twelve patients, and there was a good therapeutic response in twelve out of thirteen. One patient was dropped from the trial because treatment failed. In contrast, of seven patients who had received a similar total dose of prednisolone twice daily, three showed HPA suppression and two had lost GH responsiveness.

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mentioning

confidence: 99%

Single daily dose corticosteroid treatment.

Myles¹,

Schiller²,

Glass³

et al. 1976

Annals of the Rheumatic Diseases

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“…The therapeutic and toxic effects were similar in the two groups. Demos, Krasner, and Groel (1964) compared single daily doses of triamcinolone with divided daily doses in a large group of patients with various diseases. Relief of symptoms was similar, except in the rheumatoid arthritics, in whom the single daily dose was less effective in 22 of 76 patients.…”

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confidence: 99%